Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole
Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole
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DOI：
10.1159/000253849
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发表时间：
2010-01-01
期刊：
影响因子：
3.2
通讯作者：
Arakawa, Tetsuo
中科院分区：
文献类型：
--
作者：
Fujiwara, Yasuhiro;Kohata, Yukie;Arakawa, Tetsuo
背景和目的：在西方国家进行的几项研究证明了睡眠功能障碍与胃食管反流病（GERD）之间的关联，特别是当存在夜间胃灼热时。本研究的目的是检查日本 GERD 患者睡眠功能障碍的患病率和危险因素，以及雷贝拉唑对反流症状和睡眠功能障碍的影响。方法：共有 134 例 GERD 患者入组，其中 82 例为非糜烂性反流病（NERD）患者。患者每天接受雷贝拉唑 10 mg，持续 8 周。患者被要求在基线和治疗后 8 周完成 GERD 症状频率量表 (FSSG) 问卷和匹兹堡睡眠质量指数 (PSQI) 问卷。结果：70 名 (52.2%) 的 GERD 患者发现睡眠障碍，定义为 PSQI 评分 > 5.5。与糜烂性反流病相比，NERD 与睡眠功能障碍显着相关（OR 2.18，95% CI 1.05-4.53）。然而，其他因素，包括夜间胃灼热，与睡眠功能障碍无关。雷贝拉唑治疗显着降低了 FSSG 和 PSQI 评分。结论：GERD患者睡眠障碍发生率较高。 NERD 被确定为睡眠功能障碍的危险因素。使用质子泵抑制剂可以有效减少睡眠功能障碍。这些结果表明，与西方国家 GERD 患者相比，日本 GERD 患者睡眠功能障碍的发病机制不同。然而，酸在所有 GERD 患者的睡眠功能障碍中起着重要作用。版权所有 (C) 2010 S. Karger AG，巴塞尔
Background and Aim: Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effect of rabeprazole on reflux symptoms and sleep dysfunction in Japanese GERD patients. Methods: A total of 134 GERD patients, including 82 patients with non-erosive reflux disease (NERD), were enrolled. Patients received rabeprazole 10 mg daily for 8 weeks. Patients were asked to complete both a frequency scale for symptoms of GERD (FSSG) questionnaire and a Pittsburgh Sleep Quality Index (PSQI) questionnaire at baseline and 8 weeks after treatment. Results: Sleep dysfunction defined as a PSQI score >5.5 was found in 70 (52.2%) of the GERD patients. NERD was significantly associated with sleep dysfunction compared to erosive reflux disease (OR 2.18, 95% CI 1.05-4.53). However, other factors, including nighttime heartburn, were not associated with sleep dysfunction. Rabeprazole treatment significantly decreased both the FSSG and the PSQI score. Conclusion: The prevalence of sleep dysfunction was high among GERD patients. NERD was identified as a risk factor for sleep dysfunction. Use of a protonpump inhibitor led to an effective decrease in sleep dysfunction. These results suggest a different pathogenesis of sleep dysfunction in Japanese GERD patients compared to GERD patients in Western countries. However, acid plays an important role in sleep dysfunction in all patients with GERD. Copyright (C) 2010 S. Karger AG, Basel