Hyperphagia in pre-fed rats following oral Δ9-THC
Hyperphagia in pre-fed rats following oral Δ9-THC
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DOI：
10.1016/s0031-9384(98)00170-x
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发表时间：
1998-11-15
影响因子：
2.9
通讯作者：
Kirkham, TC
中科院分区：
文献类型：
--
作者：
Williams, CM;Rogers, PJ;Kirkham, TC
采用饲喂前模式，评估口服Delta(9)-四氢大麻酚（THC）对夜间低基线摄食的影响。在黑暗开始2小时后，成年雄性李斯特连帽大鼠（Charles River）被喂食美味的湿土豆泥饲料，分别用麻油培养液或Delta(9)-四氢大麻酚（0.063、0.12、0.25、0.5、1.0或2.0 mg/kg）处理。1小时后，允许大鼠自由进食标准食物，并在随后的24小时内监测摄入量。0.5,1.0和2.0 mg/kg剂量在测试的第一个小时内产生大量嗜食。随后，大鼠对其过量摄入进行补偿，使所有条件下的24小时摄入量相似。这些数据证实了关于外源性大麻素的增氧作用的轶事报道，并表明内源性大麻素系统在食欲调节中的关键作用。(C) 1998爱思唯尔科学有限公司
Using a pre-feed paradigm, the effects of orally-administered Delta(9)- tetrahydrocannabinol (THC) on low baseline levels of nocturnal feeding were assessed. Following 2-h access to a palatable wet mash diet at dark onset, adult male Lister hooded rats (Charles River) were treated with either sesame seed oil vehicle or Delta(9)- tetrahydrocannabinol (0.063, 0.12, 0.25, 0.5, 1.0, or 2.0 mg/kg). One hour later, rats were allowed ad libitum access to standard chow, and intakes were monitored over the subsequent 24 h. Doses of 0.5, 1.0, and 2.0 mg/kg produced substantial hyperphagia during the first hour of testing. Subsequently, rats compensated for their overconsumption so that 24-h intakes were similar in all conditions. The data confirm anecdotal reports of the orexigenic actions of exogenous cannabinoids and suggest a critical role for endogenous cannabinoid systems in the regulation of appetite. (C) 1998 Elsevier Science Inc.