Alertness function of thalamus in conflict adaptation
Alertness function of thalamus in conflict adaptation
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丘脑在冲突适应中的警觉功能
DOI：
10.1016/j.neuroimage.2016.02.048
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发表时间：
2016-05
期刊：
影响因子：
5.7
通讯作者：
Chen, Antao
中科院分区：
文献类型：
--
作者：
Wang, Xiangpeng;Zhao, Xiaoyue;Xue, Gui;Chen, Antao
冲突适应反映了基于先前经历的冲突改善当前冲突解决的能力，这对我们的目标导向行为至关重要。近年来，在讨论冲突适应的产生时，警觉性的作用越来越受到关注。然而，由于操纵警觉性的困难，在这方面取得的进展非常有限。受颜色可能影响警觉性的启发，我们对实验任务的背景颜色进行了操纵，发现在灰色和红色背景中存在显著的冲突适应，而在蓝色背景中不存在。此外，行为和功能磁共振成像结果表明，颜色对冲突适应的调制是通过改变警觉水平来实现的。特别是，蓝色背景通过抑制丘脑的警觉调节功能以及丘脑与额下回（IFG）之间的功能连接来消除冲突适应。相比之下，在灰色和红色背景下，警觉水平通常很高，丘脑和右IFG功能正常，冲突适应显着。因此，丘脑的警觉功能是冲突适应的决定性因素，丘脑和右IFG是维持这种能力的神经回路的关键节点。目前的研究结果提供了新的见解冲突适应的神经机制。
Conflict adaptation reflects the ability to improve current conflict resolution based on previously experienced conflict, which is crucial for our goal-directed behaviors. In recent years, the roles of alertness are attracting increasing attention when discussing the generation of conflict adaptation. However, due to the difficulty of manipulating alertness, very limited progress has been made in this line. Inspired by that color may affect alertness, we manipulated background color of experimental task and found that conflict adaptation significantly presented in gray and red backgrounds but did not in blue background. Furthermore, behavioral and functional magnetic resonance imaging results revealed that the modulation of color on conflict adaptation was implemented through changing alertness level. In particular, blue background eliminated conflict adaptation by damping the alertness regulating function of thalamus and the functional connectivity between thalamus and inferior frontal gyrus (IFG). In contrast, in gray and red backgrounds where alertness levels are typically high, the thalamus and the right IFG functioned normally and conflict adaptations were significant. Therefore, the alertness function of thalamus is determinant to conflict adaptation, and thalamus and right IFG are crucial nodes of the neural circuit subserving this ability. Present findings provide new insights into the neural mechanisms of conflict adaptation.
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人脑的注意力系统：20年后。
影响因子：
13.9
作者：
Petersen SE;Posner MI
通讯作者：
Posner MI
影响因子：
5.7
作者：
Power JD;Petersen SE
通讯作者：
Petersen SE
DOI：
--
发表时间：
1998
期刊：
--
影响因子：
--
作者：
R. Marrocco;M. Davidson
通讯作者：
R. Marrocco;M. Davidson
影响因子：
4.1
作者：
GRATTON, G;COLES, MGH;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
14.5
作者：
Konishi, S;Nakajima, K;Miyashita, Y
通讯作者：
Miyashita, Y