Childbearing is associated with higher incidence of the metabolic syndrome among women of reproductive age controlling for measurements before pregnancy: the CARDIA study
Childbearing is associated with higher incidence of the metabolic syndrome among women of reproductive age controlling for measurements before pregnancy: the CARDIA study
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DOI：
10.1016/j.ajog.2009.03.031
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发表时间：
2009-08-01
影响因子：
9.8
通讯作者：
Sidney, Stephen
中科院分区：
文献类型：
--
作者：
Gunderson, Erica P.;Jacobs, David R., Jr.;Sidney, Stephen
目的：我们试图前瞻性地研究育龄妇女分娩后代谢综合征（MetS）的发生率是否与生育有关。在1451名年龄为18-30岁且基线时无MetS的初产妇中（1985-1986年），并在20年内重新审查了4次，我们确定了由国家胆固醇教育计划成人治疗小组III标准定义的时间依赖性中期出生组中妊娠期糖尿病（GDM）的MetS事件：（0 [参考]，1例非GDM，2例+非GDM，1例+ GDM分娩）。互补双对数模型估计相对风险的代谢综合征之间的出生组调整种族，年龄，基线和后续covariates.RESULTS：我们确定了259事件代谢综合征的情况下，在25,246人年（10.3/1000人年）。与0出生相比，调整后的相对危险度（95%置信区间[CI]）为1.33（95% CI，0.931.90）1例非GDM，1.62（95% CI，1.16-2.26）2+非GDM（P趋势= .02）和2.43（95%CI，1.53-3.86）为1+ GDM births.CONCLUSION：增加产次与MetS的未来发展相关，独立于既往肥胖和妊娠相关体重增加。风险因GDM状态而异。
OBJECTIVE: We sought to prospectively examine whether childbearing is associated with higher incidence of the metabolic syndrome (MetS) after delivery among women of reproductive age.STUDY DESIGN: In 1451 nulliparas who were aged 18-30 years and free of the MetS at baseline (1985-1986) and reexamined up to 4 times during 20 years, we ascertained incident MetS defined by the National Cholesterol Education Program Adult Treatment Panel III criteria among time-dependent interim birth groups by gestational diabetes mellitus (GDM): (0 [referent], 1 non-GDM, 2+ non-GDM, 1 + GDM births). Complementary log-log models estimated relative hazards of the MetS among birth groups adjusted for race, age, and baseline and follow-up covariates.RESULTS: We identified 259 incident MetS cases in 25,246 person-years (10.3/1000 person-years). Compared with 0 births, adjusted relative hazards (95% confidence interval [CI]) were 1.33 (95% CI, 0.931.90) for 1 non-GDM, 1.62 (95% CI, 1.16-2.26) for 2+ non-GDM (P trend = .02), and 2.43 (95% CI, 1.53-3.86) for 1+ GDM births.CONCLUSION: Increasing parity is associated with future development of the MetS independent of prior obesity and pregnancy-related weight gain. Risk varies by GDM status.