Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients
Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients
复制标题
DOI：
10.1176/appi.ajp.160.7.1305
复制
发表时间：
2003-07-01
影响因子：
17.7
通讯作者：
Heun, R
中科院分区：
文献类型：
--
作者：
Jessen, F;Scheef, L;Heun, R
目的：在一些功能成像实验中观察到精神分裂症患者在编码或识别任务期间海马激活受损。在这项功能磁共振成像研究中，作者报告了精神分裂症患者和健康对照受试者的单词编码和识别结果，特别关注纠正行为识别成功，以防止精神分裂症患者与较低任务表现相关的偏差。方法：无论识别成功与否，首先对语言编码和识别任务进行分析。在第二次分析中，识别成功作为不感兴趣的协变量包含在块设计的编码任务中，并且从事件相关识别任务的分析中拒绝错误分类的项目。 结果：患者在识别任务上的表现比比较对象差。在两组中都观察到编码和识别过程中双侧海马的激活。仅在排除错误分类的项目后，患者在识别过程中的右侧海马激活才变得显着。组间比较显示，健康对照受试者在编码期间和识别期间左前海马体的激活程度更高。在呈现新单词后，健康受试者的双侧海马体激活程度更高，精神分裂症患者的右前海马体激活程度更高，这些新单词与识别任务中先前编码的单词混合在一起。排除错误分类的项目后，右侧海马体的差异仍然显着。结论：这项研究为精神分裂症患者言语编码和识别过程中海马体功能受到干扰提供了证据。它通过纠正行为任务表现差异可能造成的混淆，扩展了之前的研究。这种方法进一步支持了精神分裂症海马功能障碍的概念。
Objective: In patients with schizophrenia, impaired hippocampal activation either during encoding or recognition tasks has been observed in a few functional imaging experiments. In this fMRI study, the authors report results of word encoding and recognition in schizophrenia patients and healthy comparison subjects, with a special focus on correcting for behavioral recognition success in order to prevent a bias related to lower task performance in the schizophrenia patients.Method: The verbal encoding and recognition tasks were both first analyzed irrespective of recognition success. In a second analysis, recognition success was included in the block-designed encoding task as a covariate of no interest, and incorrectly classified items were rejected from the analysis of the event-related recognition task.Results: Patients performed poorer on the recognition task than the comparison subjects. Bilateral hippocampal activation during encoding and recognition was observed in both groups. Right hippocampal activation in patients during recognition became significant only after exclusion of wrongly classified items. Group comparison revealed greater activation in the healthy comparison subjects in the left anterior hippocampus during encoding and bilaterally during recognition. Greater bilateral hippocampal activation in the healthy subjects and greater activation in the right anterior hippocampus in the schizophrenic patients were revealed after presentation of novel words, which were intermixed with previously encoded words in the recognition task. After exclusion of incorrectly classified items, the differences in the right hippocampus remained significant.Conclusions: This study provides evidence for disturbed hippocampal function during verbal encoding and recognition in patients with schizophrenia. It extends previous studies by correcting for the possible confound of differences in behavioral task performance. This approach further supports the concept of hippocampal dysfunction in schizophrenia.