VIRUS-INFECTION AS A STRESSOR - INFLUENZA-VIRUS ELEVATES PLASMA-CONCENTRATIONS OF CORTICOSTERONE, AND BRAIN CONCENTRATIONS OF MHPG AND TRYPTOPHAN
VIRUS-INFECTION AS A STRESSOR - INFLUENZA-VIRUS ELEVATES PLASMA-CONCENTRATIONS OF CORTICOSTERONE, AND BRAIN CONCENTRATIONS OF MHPG AND TRYPTOPHAN
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DOI：
10.1016/0031-9384(89)90078-4
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发表时间：
1989-03-01
影响因子：
2.9
通讯作者：
SMALL, PA
中科院分区：
文献类型：
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作者：
DUNN, AJ;POWELL, ML;SMALL, PA
通过鼻内途径用流感病毒PR 8（H1N1）感染Balb/c小鼠。在随后的不同时间，检查脑样品的儿茶酚胺和吲哚胺代谢物的含量，并测量血浆皮质酮。病毒感染与体重和胸腺重量的进行性损失以及血浆皮质酮的增加有关。脾脏重量最初增加，然后下降。整个大脑中游离色氨酸和去甲肾上腺素的主要分解代谢物MHPG的大脑含量也有所增加，尤其是在下丘脑中。因此，流感病毒可以被视为一种应激源，因为它像行为应激源一样激活下丘脑-垂体-肾上腺轴，并增加大脑中色氨酸和去甲肾上腺素的浓度。这些变化类似于绵羊红细胞和纽卡斯尔病病毒（免疫系统的非感染性激活剂）给药后观察到的变化，表明去甲肾上腺素能和HPA激活是抗原刺激的常见伴随物。这些作用的介质可能是由活化的巨噬细胞释放的白细胞介素-1。应该注意的是，感染病毒的动物可能会表现出类似压力的内分泌和神经化学变化。
Balb/c mice were infected with influenza virus PR8 (H1N1) by the intranasal route. At various subsequent times, brain samples were examined for their content of catecholamine and indoleamine metabolites, and plasma corticosterone was measured. Virus infection was associated with a progressive loss of body and thymus weights, and an increase in plasma corticosterone. Spleen weight initially increased then decreased. There were also increases in the cerebral content of free tryptophan throughout the brain, and of MHPG, a major catabolite of norepinephrine, especially prominent in the hypothalamus. Thus influenza virus can be regarded as a stressor because, like behavioral stressors, it activates the hypothalamic-pituitary-adrenal axis, and increases cerebral concentrations of tryptophan and norepinephrine catabolites. These changes resemble those observed following administration of sheep red blood cells and Newcastle disease virus, noninfectious activators of the immune system, suggesting that noradrenergic and HPA activation are common concomitants of antigenic stimulation. The mediator of these effects may be interleukin-1 released by activated macrophages. It should be noted that animals infected with viruses can be expected to exhibit stress-like endocrine and neurochemical changes.