Establishment of a new cell line derived from a human gliosarcoma.
Establishment of a new cell line derived from a human gliosarcoma.
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DOI：
10.1227/00006123-199202000-00013
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发表时间：
1992-02
期刊：
影响因子：
4.8
通讯作者：
K. Iwasaki;H. Kikuchi;S. Miyatake;S. Kondo;Y. Oda
中科院分区：
文献类型：
--
作者：
K. Iwasaki;H. Kikuchi;S. Miyatake;S. Kondo;Y. Oda
从人胶质肉瘤中建立了一个永久性细胞系GI-1，并对其特性进行了研究。原始肿瘤是两种不同肿瘤的混合物，具有胶质瘤和肉瘤的成分。所建立的细胞系表达各种间充质抗原，但不表达神经上皮抗原。然而，值得注意的是，该细胞系在无胸腺小鼠中接种后产生具有人类神经胶质瘤形态特征的肿瘤。组织培养和异种移植的病理特征的对比是独特的，这一发现表明GI-1细胞系可能具有胶质瘤和肉瘤的特征。
A permanent cell line, GI-1, was established from a human gliosarcoma, and its characteristics were investigated. The original tumor was a mixture of two different neoplasms which had components of both glioma and sarcoma. The established cell line expressed various mesenchymal antigens, but not neuroepithelial antigens. It was noted, however, that the cell line produced tumors with the morphological features of human glioma after inoculation in athymic mice. The contrast of the pathological characteristics in tissue culture and in xenograft was unique, and this finding suggests that the GI-1 cell line may have the features of both glioma and sarcoma.