Non-invasive characterization of real-time bladder sensation using accelerated hydration and a novel sensation meter: An initial experience.
Non-invasive characterization of real-time bladder sensation using accelerated hydration and a novel sensation meter: An initial experience.
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DOI：
10.1002/nau.23137
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发表时间：
2017-06
影响因子：
2
通讯作者：
Klausner AP
中科院分区：
文献类型：
--
作者：
Nagle AS;Speich JE;De Wachter SG;Ghamarian PP;Le DM;Colhoun AF;Ratz PH;Barbee RW;Klausner AP
本研究的目的是开发一种非侵入性、客观且无提示的方法来表征实时膀胱感觉。患有或不患有膀胱过度活动症（OAB）的志愿者前瞻性地参加了一项初步的加速水合作用研究。参与者饮用 2L Gatorade-G2®，并使用新颖的触摸屏“感觉计”记录实时感觉（0-100% 范围）和标准化言语感觉阈值。在一部分参与者的充填过程中记录了 3D 膀胱超声图像。记录两个连续完整的填充-空隙循环的感觉数据。获得了 14 名正常参与者和 12 名 OAB 参与者的数据（ICIq-OAB-5a = 0 vs. ≥3）。与 fill1 相比，fill2 的填充持续时间减少，但体积没有显着变化。在正常人中，相邻的言语感觉阈值（充盈内）没有重叠，并且相同的阈值（充盈之间）相似，证明了膀胱容量％程度之间的有效区分。在 OAB 中，识别了填充内重叠和填充间差异。实时%容量-感觉曲线在法线中从 fill1 左移到 fill2，与预期的粘弹性行为一致，但在 OAB 中意外右移。 3D 超声体积数据显示，填充率开始缓慢，并随着终点的变化而逐渐增加。这项研究建立了一种非侵入性方法，使用两次填充加速水合方案和感觉计来评估实时膀胱感觉。 OAB 的言语阈值不一致，OAB %能力-感觉曲线的右移表明潜在的生物力学和/或敏化变化。该方法可用于以完全非侵入性的方式获取有关不同形式的 OAB 的有价值的信息。
The purpose of this investigation was to develop a non-invasive, objective, and unprompted method to characterize real-time bladder sensation. Volunteers with and without overactive bladder (OAB) were prospectively enrolled in a preliminary accelerated hydration study. Participants drank 2L Gatorade-G2® and recorded real-time sensation (0–100% scale) and standardized verbal sensory thresholds using a novel, touch-screen “sensation meter.” 3D bladder ultrasound images were recorded throughout fillings for a subset of participants. Sensation data were recorded for two consecutive complete fill-void cycles. Data from 14 normal and 12 OAB participants were obtained (ICIq-OAB-5a = 0 vs. ≥3). Filling duration decreased in fill2 compared to fill1, but volume did not significantly change. In normals, adjacent verbal sensory thresholds (within fill) showed no overlap, and identical thresholds (between fill) were similar, demonstrating effective differentiation between degrees of %bladder capacity. In OAB, within-fill overlaps and between-fill differences were identified. Real-time %capacity-sensation curves left shifted from fill1 to fill2 in normals, consistent with expected viscoelastic behavior, but unexpectedly right shifted in OAB. 3D ultrasound volume data showed that fill rates started slowly and ramped up with variable end points. This study establishes a non-invasive means to evaluate real-time bladder sensation using a two-fill accelerated hydration protocol and a sensation meter. Verbal thresholds were inconsistent in OAB, and the right shift in OAB %capacity–sensation curve suggests potential biomechanical and/or sensitization changes. This methodology could be used to gain valuable information on different forms of OAB in a completely non-invasive way.