The role of SNARE proteins in trafficking and function of neurotransmitter transporters.
The role of SNARE proteins in trafficking and function of neurotransmitter transporters.
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DOI：
10.1007/3-540-29784-7_9
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发表时间：
2006
影响因子：
--
通讯作者：
M. Quick
中科院分区：
文献类型：
--
作者：
M. Quick
囊泡融合的SNARE假说提出，一系列蛋白质-蛋白质相互作用控制囊泡向各种膜靶点（如高尔基体网络和质膜）的递送。这一过程中的关键参与者包括膜蛋白的突触融合蛋白家族的成员。syntaxin 1A是这个家族中发现的第一个成员，它在含神经递质的囊泡与神经元突触前膜的对接和融合中起着重要作用。突触融合蛋白1A和其他突触融合蛋白家族成员也被证明与多种离子通道相互作用并直接调节多种离子通道。最近，质膜神经递质转运蛋白家族，部分功能是控制脑中递质水平的蛋白质，已被证明是突触融合蛋白1A调节的直接靶点。这种调节既涉及转运蛋白的贩运，也涉及通过转运蛋白的离子和递质通量的控制。在这一章中，突触融合蛋白转运蛋白的相互作用的功能影响进行了审查，并考虑这种相互作用可能如何调节神经元信号。
The SNARE hypothesis of vesicle fusion proposes that a series of protein-protein interactions governs the delivery of vesicles to various membrane targets such as the Golgi network and the plasma membrane. Key players in this process include members of the syntaxin family of membrane proteins. The first member identified in this family, syntaxin 1A, plays an essential role in the docking and fusion of neurotransmitter-containing vesicles to the presynaptic membrane of neurons. Syntaxin 1A and other syntaxin family members have also been shown to interact with, and directly regulate, a variety of ion channels. More recently, the family of plasma membrane neurotransmitter transporters, proteins that function in part to control transmitter levels in brain, have been shown to be direct targets of syntaxin 1A regulation. This regulation involves both the trafficking of transporters as well as the control of ion and transmitter flux through transporters. In this chapter, the functional effects of syntaxin-transporter interactions are reviewed, and how such interactions may regulate neuronal signaling are considered.