DECREASED INNATE IMMUNE CYTOKINE RESPONSES CORRELATE WITH DISEASE SEVERITY IN CHILDREN WITH RESPIRATORY SYNCYTIAL VIRUS AND HUMAN RHINOVIRUS BRONCHIOLITIS
DECREASED INNATE IMMUNE CYTOKINE RESPONSES CORRELATE WITH DISEASE SEVERITY IN CHILDREN WITH RESPIRATORY SYNCYTIAL VIRUS AND HUMAN RHINOVIRUS BRONCHIOLITIS
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DOI：
10.1097/inf.0b013e31822dc8c1
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发表时间：
2012-01-01
影响因子：
3.6
通讯作者：
Mejias, Asuncion
中科院分区：
文献类型：
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作者：
Garcia, Carla;Soriano-Fallas, Alejandra;Mejias, Asuncion
儿童呼吸道合胞病毒（RSV）和人鼻病毒下呼吸道感染的免疫发病机制仍有待确定。我们测量了患有RSV或人鼻病毒下呼吸道感染的婴儿的29种细胞因子的鼻洗液浓度。在这两种感染中，RSV和先天免疫细胞因子中的干扰素-γ浓度与疾病严重程度呈负相关。
The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-gamma in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.