H. Influenzæ Meningitis: A Controlled Study of Treatment with Ampicillin
H. Influenzæ Meningitis: A Controlled Study of Treatment with Ampicillin
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H. 流感脑膜炎：氨苄青霉素治疗的对照研究
DOI：
10.1136/pgmj.40.suppl.119
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发表时间：
1964
影响因子：
5.1
通讯作者：
B. Portnoy
中科院分区：
文献类型：
--
作者：
L. Thrupp;J. Leedom;D. Ivler;P. Wehrle;J. F. Brown;A. Mathies;B. Portnoy
然而，在脑膜炎的动物中，几乎只在具有脑膜炎的强烈迹象的动物中发现了这种药物。氨苄青霉素对实验性嗜血杆菌脑膜炎有明显的治疗作用，特别是大剂量时。脑膜的病理变化与临床表现相一致。然而，在用β-链球菌和流感嗜血杆菌进行的实验中，甚至在脑膜炎的迹象出现之前，就可以看出轻微的变化。
gitis, however, the drug was found in brain almost exclusively in animals with intensive signs of meningitis. Ampicillin, particularly in large doses, had a distinct therapeutic effect in experimental Hemophilus meningitis The pathological changes in the meninges corresponded to the clinical picture. In experiments with /3-streptococci and Haemophilus influenze, however, milld changes were discernible even before signs of meningitis had appeared.