Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis
Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis
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DOI：
10.1161/hc4501.098925
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发表时间：
2001-11-13
期刊：
影响因子：
37.8
通讯作者：
Mannucci, PM
中科院分区：
文献类型：
--
作者：
Cattaneo, M;Lombardi, R;Mannucci, PM
背景-口服蛋氨酸负荷（PML）前后血浆总同型半胱氨酸（tHcy）水平升高与深静脉血栓形成（DVT）风险升高相关。我们研究了血浆中参与同型半胱氨酸代谢的B族维生素水平是否与DVT风险升高相关。方法和结果-我们将397例既往DVT患者与585例匹配的健康对照者进行了比较。测定血浆叶酸、维生素B-12、维生素B-6水平以及空腹和PML tHcy水平。在调整DVT的既定危险因素后，与高（>第95百分位数）空腹水平和PML tHcy升高相关的DVT OR分别为2.1（95% CI，1.2 - 3.4）和2.4（95% CI，1.5 - 3.9）。空腹血浆tHcy水平和PML升高与维生素水平呈负相关。叶酸水平最低四分位数与最高四分位数相比的粗OR为1.5（95% CI，1.1至2.1），B-6水平最低和第二四分位数与最高四分位数相比的粗OR为1.5（95% CI，1.0至2.1）。然而，在校正了已确定的风险因素和空腹及PML tHcy后，仅最低和第二个四分位数中B-6水平的OR仍具有统计学显著性（最低四分位数：OR，1.8; 95% CI，1.2至2.8，第二四分位数，OR，1.9;结论-高空腹和PML tHcy及低维生素B-6血浆水平与DVT风险升高相关，独立于DVT的既定风险因素。低维生素B水平与DVT风险的相关性与空腹和PML tHcy水平无关。
Background-Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT.Methods and Results-We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B-12, vitamin B-6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (> 95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.1), and that for B-6 levels in the lowest and second quartiles compared with the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B-6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95% Cl, 1.2 to 2.8, second quartile, OR, 1.9; 95% CI, 1.3 to 2.9).Conclusions-High fasting and PML tHcy and low vitamin B-6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B, levels with the risk for DVT is independent of fasting and PML tHcy levels.