Pathological and clinical effects of interleukin-6 on human myocarditis
Pathological and clinical effects of interleukin-6 on human myocarditis
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DOI：
10.1016/j.jjcc.2021.03.003
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发表时间：
2021-06-18
影响因子：
2.5
通讯作者：
Ito, Hiroshi
中科院分区：
文献类型：
--
作者：
Amioka, Naofumi;Nakamura, Kazufumi;Ito, Hiroshi
背景：大量基础研究表明白介素 6 (IL-6) 与心肌炎的发生或严重程度之间存在关系。然而，尚无研究评估IL-6水平对心肌炎患者的影响。方法：我们招募了对照患者（n = 12）和连续的急性心肌炎患者（n = 13），包括淋巴细胞性、嗜酸性粒细胞性和巨细胞性心肌炎，并研究了IL-6对人类心肌炎的病理和临床效果。结果：心肌炎患者血清IL-6水平（16.7[9.9,103.8]pg/mL）显着高于对照患者（1.4[1.0,1.9]pg/mL）（P<0.001）。免疫组织化学分析显示，所有心肌炎患者心内膜心肌活检样本的浸润炎症细胞中均表达IL-6。此外，血清IL-6水平的对数转换值与血清肌酸激酶（CK）水平、CK-MB水平、峰值CK水平、峰值CK-MB水平和C反应蛋白水平呈显着正相关（所有P
Background: Numerous basic studies have shown a relationship between interleukin-6 (IL-6) and the development or severity of myocarditis. However, there has been no study in which the effect of IL-6 levels in patients with myocarditis was evaluated. Methods: We enrolled control patients ( n = 12) and consecutive patients with acute myocarditis ( n = 13), including lymphocytic, eosinophilic, and giant cell myocarditis, and investigated the pathological and clinical effects of IL-6 on human myocarditis. Results: The serum IL-6 level in patients with myocarditis (16.7 [9.9, 103.8] pg/mL) was significantly higher than that in the control patients (1.4 [1.0, 1.9] pg/mL) ( P < 0.001). Immunohistochemical analysis showed that IL-6 was expressed in infiltrating inflammatory cells of endomyocardial biopsy samples from all patients with myocarditis. Moreover, the log-transformed value of serum IL-6 level showed significant positive correlations with serum creatine kinase (CK) level, CK-MB level, peak CK level, peak CK-MB level and C-reactive protein level (all P