Basal ganglia volumes in children with attention-deficit hyperactivity disorder
Basal ganglia volumes in children with attention-deficit hyperactivity disorder
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DOI：
10.1177/088307389601100210
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发表时间：
1996-03-01
影响因子：
1.9
通讯作者：
Denckla, MB
中科院分区：
文献类型：
--
作者：
Aylward, EH;Reiss, AL;Denckla, MB
先前的研究表明，与单独患有抽动秽语综合征和正常对照的儿童相比，同时诊断抽动秽语综合征和注意力缺陷多动障碍（ADHD）的儿童的左侧苍白球体积减少。本研究的目的是确定仅患有多动症的儿童是否也出现苍白球或其他基底神经节结构的体积缩小。受试者包括 10 名患有 ADHD 的男孩、16 名患有抽动秽语综合征和 ADHD 的男孩以及 11 名正常对照男孩。各组的年龄相匹配。患有多动症的男孩在年龄、惯用手和智商方面与 16 名患有图雷特综合征和多动症的男孩中的 10 名进行了单独匹配，测量了尾状核、壳核和苍白球的体积，并根据脑体积进行了校正。患有多动症的男孩的左侧苍白球体积和总苍白球体积（根据脑体积进行校正）明显小于正常对照组。抽动秽语综合症加多动症组在任何一项指标上都与多动症组没有差异。我们的结论是，苍白球体积小，尤其是左侧，与多动症相关。
Previous research has demonstrated volume reduction of the left globus pallidus in children with the codiagnoses of Tourette syndrome and attention-deficit hyperactivity disorder (ADHD), in comparison with children who have Tourette syndrome alone and with normal controls. The purpose of this study was to determine whether children with ADHD alone also had volume reduction of the globus pallidus or other basal ganglia structures. Subjects were 10 boys with ADHD, 16 boys with Tourette syndrome and ADHD, and 11 normal control boys. Groups were matched for age. Boys with ADHD were individually matched for age, handedness, and IQ to 10 of the 16 boys with Tourette syndrome and ADHD, Volumes of caudate, putamen, and globus pallidus were measured and corrected for brain volume. The boys with ADHD had significantly smaller left globus pallidus volume and total globus pallidus volume (corrected for brain volume) than the normal controls. The Tourette syndrome plus ADHD group did not differ from the ADHD group on any of the measures. We conclude that small globus pallidus volume, particularly on the left side, is associated with ADHD.