Endocardial and epicardial activation pathways of the canine right atrium.
Endocardial and epicardial activation pathways of the canine right atrium.
复制标题
犬右心房的心内膜和心外膜激活途径。
DOI：
10.1152/ajplegacy.1971.220.1.1
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
R. V. van Dam
中科院分区：
文献类型：
--
作者：
D. Goodman;A. B. van der Steen;R. V. van Dam
犬右心房的心内膜和心外膜激动通路。上午好。JS Physiol。220(L)：L-L 1.197 1.右心房1.在朗宁多夫灌流的犬心脏上，研究了窦性心律和刺激冠状静脉窦附近和右心房其他部位时的心外膜和心内膜活动。对照实验显示与心外膜原位激活密切相关，在灌流过程中传导速度增加约5-20岁。终脊两个方向的原位总传导速度为0.9~L 2米/支，平行于房顶梳状肌0.88米/支，垂直于这些肌束0.56米/支。在一次实验中，我们发现沿巴赫曼束的传导速度为3m/set。沿着结间束的快速传导--可能巴赫-曼氏束除外--可以用心肌纤维的平行排列来解释，而不需要特殊纤维的参与。后束是最稳定的结间连接，部分实验中前束传导不连续，中束不一致。卵圆窝的边缘是传播激活的屏障，使其绕过卵圆窝。近几年来，心房中存在一种特殊的传导系统的问题经常被讨论。James的形态学研究证实了前、中、后结间束的存在。最近，Holinger等人的电生理学研究表明，在窦性心律期间，沿着这些束的相对快速的传导已被证实。(9)谁从外科角度研究了他们。特化纤维和纤维束已经在节间束中、在不同的标本中和在不同的物种中被证明，无论是通过组织学(16，21)还是通过包括微电极在内的电生理技术。Merideth和Ttes(16)给出了一个很好的评论。然而，在起源于窦房结外的节律时，节间束中是否也存在优先传导，以及特化的纤维系统是否确实有助于沿着这些通路的兴奋的快速传导，目前还没有得到证实。事实上，有证据表明，在没有特殊纤维参与的情况下，相对较快的传导发生在包括终脊在内的粗大的房室心肌束上。为了确定特殊通路是否在犬完整的心房中起作用，我们仔细分析了右心房的心外膜和心内膜表面以及…邻近部分的兴奋。
Endocardial and epicardial activation pathways of the canine right atrium. Am. JS Physiol. 220(l) : l-l 1. 197 1 .-Right atria1 epicardial and endocardial activation was explored in Langendorff-perfused canine hearts during sinus rhythm and during stimulation near the coronary sinus and elsewhere in the right atrium. Control experiments demonstrate close correlation to epicardial activation in situ; conduction velocity increased about 5-20y0 during perfusion. In situ overall conduction velocity in two directions along the crista terminalis was 0.9-l .2 m/set, parallel to the pectinate muscles of the atria1 roof 0.88 m/set, and perpendicular to these muscle bundles 0.56 m/set. In one experiment a conduction velocity along Bachmann's bundle of 3 m/set was found. The rapid conduction along the internodal tracts-with the possible exception of Bach-mann's bundle-can be accounted for by the parallel arrangement of myocardial fibers and does not require participation of specialized fibers. The posterior tract was the most stable inter-nodal connection, conduction along the anterior tract was not continuous in some experiments, and the middle tract was inconsistent. The limbus of the fossa ovalis is a barrier to propagated activation, deflecting it around the fossa ovalis. THE PRESENCE of a specialized conduction system in the atria has been discussed frequently in recent years. The existence of the anterior, middle, and posterior internodal tracts has been proven by the morphological studies of James (11). Recently, relatively fast conduction along these tracts during sinus rhythm has been demonstrated by the electrophysio-logical investigations of Holsinger et al. (9) who studied-them from a surgical point of view. Specialized fibers and fiber tracts have been demonstrated in the internodal tracts, in various preparations and in (different species, both by histological (16, 21) and by ,electrophysiological techniques including microelectrode An excellent review has been given by Merideth and Titus (16). However, it has not been demonstrated whether preferential conduction also occurs in the internodal tracts during rhythms originating outside the sinus node, nor whether the specialized fiber systems indeed contribute to fast conduction of excita-tion along these pathways. In fact, evidence has been found that relatively fast conduction occurs along thick bundles of atria1 myocardium, including the crista terminalis, without the participation of specialized fibers (10, 18). In order to determine whether specialized paths do function as such in the intact atria of the dog, we carefully analyzed excitation at the epicardial and endocardial surfaces of the right atrium and adjacent parts of the …