Inert to bioactive - A multidimensional spectrum
Inert to bioactive - A multidimensional spectrum
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DOI：
10.1016/j.dental.2021.11.002
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发表时间：
2022-01-19
期刊：
影响因子：
5
通讯作者：
Smith, Anthony J.
中科院分区：
文献类型：
--
作者：
Darvell, Brian W.;Smith, Anthony J.
目的：阐明生物系统中接触组织材料的术语及其应用。方法：审查在这种情况下发生的生物和化学反应的性质，以期对行为类型进行分类，从而对材料类型进行分类。结果：确定了一系列行为类型，并具有明确的诊断特征。因此，材料可以相应地分类，有可能表现出不止一种类型的行为。“生物活性”的结论是完全依赖于自然生物过程的调节，但不包括药物作用。意义：明确生物系统中材料及其行为的特征和标签将有助于对文献的解释、实验的设计和未来的研究方向。
Objective: To clarify the terminology and its application in the context of materials placed in contact with tissues in living systems. Methods: Review the nature of both the biological and chemical reactions occurring in such contexts with a view to a classification of types of behaviour and thus types of material. Results: A range of types of behaviour was identified with clear diagnostic characteristics. Materials could thus be classified accordingly, with the possibility of more than one type of behaviour being exhibited. 'Bioactivity' was concluded to depend solely on the modulation of a natural biological process, but excluding pharmaceutical action. Significance: Clarity in the characterisation and labelling of materials and their behaviours in biological systems will benefit the interpretation of the literature, the design of experiments, and future research directions.