[Identification of a molecular mechanism for actions of existing medicines and its application for drug development].
[Identification of a molecular mechanism for actions of existing medicines and its application for drug development].
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[现有药物作用分子机制的鉴定及其在药物开发中的应用]。
DOI：
10.1248/yakushi.132.713
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
T. Mizushima
中科院分区：
文献类型：
--
作者：
T. Mizushima
作为一种新的药物发现和开发策略，我们建议建立药物再谱策略。在这一战略中，在分子水平上全面检查已证实对人体安全性和药代动力学作用的现有药物的作用，并将结果用于新药开发。例如，确定药物副作用的潜在机制使我们能够开发更安全的药物。研究结果也可用于开发现有药物，用作治疗其他疾病的药物。促进这一研究战略可以为制药公司的药物发现和开发提供突破。
As a new strategy for drug discovery and development, we propose here the establishment of drug re-profiling strategy. In this strategy, the actions of existing medicines, whose safety and pharmacokinetic effects in humans have been confirmed already, are examined comprehensively at the molecular level and the results are used for the development of new medicines. For example, identification of the mechanisms underlying the side effects of medicines enables us to develop safer drugs. The results can also be used for developing existing drugs for use as medicines in treatment of other diseases. Promoting this research strategy could provide breakthroughs in drug discovery and development by pharmaceutical companies.