Estimating the Range of Obesity Treatment Response Variability in Humans: Methods and Illustrations
Estimating the Range of Obesity Treatment Response Variability in Humans: Methods and Illustrations
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DOI：
10.1159/000351738
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发表时间：
2013-01-01
期刊：
影响因子：
1.8
通讯作者：
Gadbury, Gary L.
中科院分区：
文献类型：
--
作者：
Kaiser, Kathryn A.;Gadbury, Gary L.
背景/目标：全球范围内人类肥胖症的患病率不断上升，研究重点是各种干预措施，导致高度不同程度的体重减轻（WL）。基因组测试的出现量化了遗传因素对肥胖发展的贡献以及亚群之间风险等位基因的种族/民族变异的估计。最近的研究已经检查了WL干预措施有效性的遗传关联，但迄今为止无法解释观察到的大部分方差。研究方法：我们描述并提供了两个例证的统计方法来估计WL治疗反应异质性（TRH）的上限和下限的基因型数据的情况下，使用已发表的汇总统计和WL研究的原始数据集。结果：32项研究有一些证据表明，相对于对照干预措施，平均治疗效果为正。这32项研究中有12项报告了WL TRH。在这12个样本中，有3个样本的估计比例>5%，结果与平均效应相反。在原始数据集中，腰围变化的界限估计显示男性的范围比女性更窄。结论：未来的研究可能能够利用多种方法，包括我们描述的方法，来识别和量化WL或相关结果研究中TRH的存在。(C)2013 S. Karger AG，巴塞尔
Background/Aims: The rising prevalence of human obesity worldwide has focused research on a variety of interventions that result in highly varied degrees of weight loss (WL). The advent of genomic testing has quantified estimates of both the contribution of genetic factors to the development of obesity as well as racial/ethnic variation of risk alleles across subpopulations. More recent studies have examined genetic associations with effectiveness of WL interventions, but to date are unable to explain a large proportion of the variance observed. Methods: We describe and provide two illustrations of statistical methods to estimate upper and lower bounds of WL treatment response heterogeneity (TRH) in the absence of genotypic data, using published summary statistics and a raw data set from WL studies. Results: Thirty-two studies had some evidence of a positive mean treatment effect with respect to the control intervention. Twelve of these 32 studies reported WL TRH. Of these 12, 3 demonstrated an estimated proportion of >5% of the sampled population having an outcome opposite the mean effect. In the raw data set, bounds estimations for change in waist circumference revealed tighter ranges in men than women. Conclusion: Future studies may be able to take advantage of multiple approaches, including the method we describe, to identify and quantify the presence of TRH in studies of WL or related outcomes. (C) 2013 S. Karger AG, Basel