Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy
Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy
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DOI：
10.1111/j.1365-2133.2010.09992.x
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发表时间：
2010-12-01
影响因子：
10.3
通讯作者：
Santos-Silva, A.
中科院分区：
文献类型：
--
作者：
Coimbra, S.;Oliveira, H.;Santos-Silva, A.
目的了解白细胞介素（IL）-22、IL-17、IL-23、IL-8、血管内皮生长因子（VEGF）和肿瘤坏死因子（TNF）-α在寻常型银屑病发病中的作用及相互关系，探讨其在银屑病发病前、发病后的水平及变化，为银屑病的治疗提供理论依据。补骨脂素-紫外线A（PUVA）和窄谱紫外线B（NB-UVB）治疗期间和治疗后。方法进行了一项横断面和纵向研究（n = 34）--在NB-UVB和PUVA治疗前（T0）以及治疗3周（T3）、6周（T6）和12周（T12）进行;结果与对照组（n = 20）比较，T0时，除TNF-α外，所有指标均显著升高（P < 0. 05）。NB-UVB和PUVA治疗均在T3时显著降低TNF-α和IL 23;在T6时显著降低IL 22和IL 17;在T12时所有参数和银屑病面积和严重程度指数显著降低。结论银屑病是一种细胞因子网络紊乱的复杂疾病，IL-22、IL-17、IL-23、IL-8、TNF-α和VEGF的表达均受到干扰。NB-UVB和PUVA随访研究提示，IL-23/Th 17轴的降低可能在银屑病发病机制中起重要作用。对这些和其他疗法治疗的银屑病患者进行进一步的随访研究，可能有助于了解银屑病细胞因子网络的紊乱，并间接了解其发病机制。
Background Several cross-sectional studies have shown that different cytokines and growth factors are enhanced in psoriasis.Objectives We aimed to understand the role/relation of interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor (VEGF) and tumour necrosis factor (TNF)-alpha in psoriasis vulgaris, addressing their levels and changes before, during and after psoralen-ultraviolet A (PUVA) and narrowband ultraviolet B (NB-UVB) treatment.Methods A cross-sectional and a longitudinal study (n = 34) - before (T0) and at 3 (T3), 6 (T6) and 12 (T12) weeks of NB-UVB and PUVA therapy - were performed; 17 patients started NB-UVB and 17 PUVA, and IL-22, IL-17, IL-23, IL-8, TNF-alpha and VEGF levels were evaluated.Results At T0, compared with controls (n = 20), all the parameters were significantly higher in patients, except for TNF-alpha. Both NB-UVB and PUVA treatment gave, at T3, a significant decrease in TNF-alpha and IL 23; IL 22 and IL 17 decreased significantly at T6; all parameters and Psoriasis Area and Severity Index decreased significantly at T12. However, in both groups, at T12, VEGF was still significantly higher than control.Conclusions Psoriasis seems to be a complex disease in which the cytokine network is disturbed, namely in levels of IL-22, IL-17, IL-23, IL-8, TNF-alpha and VEGF. NB-UVB and PUVA follow-up studies suggested that the reduction in the IL-23/Th17 axis might be important in the pathogenic mechanisms of psoriasis. Further follow-up studies of patients with psoriasis treated with these and other therapies could be very helpful for the understanding of the disturbance in the cytokine network in psoriasis and indirectly in its pathogenesis.