Catecholamine-containing neurones and electrical self-stimulation: 1. a review of some data
Catecholamine-containing neurones and electrical self-stimulation: 1. a review of some data
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含儿茶酚胺的神经元和电自刺激：1.一些数据的回顾
DOI：
10.1017/s0033291700045232
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发表时间：
1972
影响因子：
6.9
通讯作者：
T. Crow
中科院分区：
文献类型：
--
作者：
T. Crow
概要 概要 对支持电自刺激的电极部位在大脑中的位置的实验数据进行了回顾。之前的所有研究都一致认为，这种行为最容易从外侧下丘脑部位引发，这些部位大约对应于被称为“内侧前脑束”的纤维通路。一些脑干电极部位将支持自我刺激。实验总结表明，自我刺激呈阳性的电极尖端位置与两个区域中含儿茶酚胺的神经元的位置之间存在相关性：（1）腹侧中脑中含多巴胺的细胞区域（Dahlström和Fuxe的细胞体组A9和AIO，1964），以及（2）蓝斑中含去甲肾上腺素的细胞区域（A6）组）。这两个细胞体群产生轴突，轴突穿过内侧前脑束，形成广泛分布在前脑的末端系统。提出的假设是，在大多数情况下，电自刺激是由这些含儿茶酚胺系统中的一个或两个的激活引起的。
Synopsis SYNOPSIS Experimental data on the location in the brain of electrode sites supporting electrical self-stimulation are reviewed. All previous studies are in agreement that the behaviour is most easily elicited from lateral hypothalamic sites corresponding approximately to the fibre pathways known as the ‘medial forebrain bundle’. Some brainstem electrode sites will support self-stimulation. Experiments are summarized which indicate that there is a correlation between the sites of electrode tips positive for self-stimulation and the location of catecholamine-containing neurones in two regions: (1) in the region of the dopamine-containing cells in the ventral mesencephalon (cell-body groups A9 and AIO of Dahlstr¨m and Fuxe, 1964), and (2) in the region of the noradrenaline-containing cells of the locus coeruleus (A6 group). These two cell-body groups give rise to axons which pass through the medial forebrain bundle to form terminal systems with a widespread distribution in the prosencephalon. The hypothesis is advanced that electrical self-stimulation results in the majority of cases from activation of one or both of these catecholamine-containing systems.