The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice.
The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice.
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DOI：
10.1097/wnr.0b013e328338ba18
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发表时间：
2010-04-21
期刊：
影响因子：
1.7
通讯作者：
Comi AM
中科院分区：
文献类型：
--
作者：
Markowitz GJ;Kadam SD;Boothe DM;Irving ND;Comi AM
Rodents eliminate antiepileptic drugs (AEDs) faster than humans, creating challenges for designing clinically-relevant protocols. Half-lives of AEDs in immature mice are unknown. The pharmacokinetics of commonly-used AEDs were examined in CD1 mice using a single-dose protocol at post-natal day 19. Following intraperitoneal therapeutic dosing, blood serum concentrations spanning 1–48 hours post-administration and corresponding brain tissue concentrations at 4 hours were analyzed. Half-lives of valproate, phenobarbital, diazepam (and metabolites), phenytoin, and levetiracetam were 2.6, 15.8, 22.3, 16.3, and 3.2 hours respectively, compared to 0.8, 7.5, 7.7, 16.0, and 1.5 hours reported for adult mice. Brain-to-blood ratios were comparable to adult ratios. AEDs tested had longer half-lives and maintained therapeutic plasma concentrations longer than reported in mature mice, making clinically-relevant protocols feasible.
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影响因子：
1.8
作者：
Benedetti, MS;Coupez, R;Baltes, E
通讯作者：
Baltes, E
影响因子：
3.4
作者：
GREENBLATT, DJ;SETHY, VH
通讯作者：
SETHY, VH
DOI：
10.1111/j.1749-6632.2003.tb07517.x
发表时间：
2003-01-01
期刊：
NEUROPROTECTIVE AGENTS
影响因子：
--
作者：
Bittigau, P;Sifringer, M;Ikonomidou, C
通讯作者：
Ikonomidou, C
影响因子：
1.4
作者：
Daood M;Tsai C;Ahdab-Barmada M;Watchko JF
通讯作者：
Watchko JF
DOI：
10.1016/0165-3806(96)00117-4
发表时间：
1996-10-23
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Kniesel, U;Risau, W;Wolburg, H
通讯作者：
Wolburg, H