Performance of [18F]flutemetamol amyloid imaging against the neuritic plaque component of CERAD and the current (2012) NIA-AA recommendations for the neuropathologic diagnosis of Alzheimer's disease.
Performance of [18F]flutemetamol amyloid imaging against the neuritic plaque component of CERAD and the current (2012) NIA-AA recommendations for the neuropathologic diagnosis of Alzheimer's disease.
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DOI：
10.1016/j.dadm.2017.06.001
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Curtis, Craig
中科院分区：
文献类型：
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作者：
Salloway, Stephen;Gamez, Jose E;Curtis, Craig
简介：淀粉样蛋白示踪剂[18F] flutemetalography的性能进行了评估，对三个病理学标准的真理（SoT）措施，包括神经炎斑块（CERAD“原始”和“修改”和2012年NIA-AA指南的淀粉样蛋白成分）。方法：[18F] flutemetalography成像后，106名死亡的临终患者进行了死后大脑检查淀粉样蛋白斑块负荷。由五名独立的电子培训过的阅片员进行的盲态正电子发射断层扫描解释与病理学测量进行了比较。根据SoT，大多数图像解释的敏感性和特异性分别为，“原始CERAD”为91. 9%和87. 5%，“改良CERAD”为90. 8%和90. 0%，2012年NIA-AA标准为85.7%和100%。讨论：CERAD标准的高准确性表明，[18 F] flutemetrine主要反映神经炎淀粉样斑块密度。然而，使用CERAD标准作为SoT可能会导致一些假阳性结果，因为存在弥漫性斑块，当将正电子发射断层扫描读数与2012年NIA-AA标准进行比较时会考虑到这一点。
INTRODUCTION: Performance of the amyloid tracer [18F]flutemetamol was evaluated against three pathologystandard of truth (SoT) measures including neuritic plaques (CERAD "original" and "modified" and the amyloid component of the 2012 NIA-AA guidelines).METHODS: After [18F]flutemetamol imaging, 106 end-of-life patients who died underwent postmortem brain examination for amyloid plaque load. Blinded positron emission tomography scan interpretations by five independent electronically trained readers were compared with pathology measures.RESULTS: By SoT, sensitivity and specificity of majority image interpretations were, respectively, 91.9% and 87.5% with "original CERAD," 90.8% and 90.0% with "modified CERAD," and 85.7% and 100% with the 2012 NIA-AA criteria.DISCUSSION: The high accuracy of either CERAD criteria suggests that [18F]flutemetamol predominantly reflects neuritic amyloid plaque density. However, the use of CERAD criteria as the SoT can result in some false-positive results because of the presence of diffuse plaques, which are accounted for when the positron emission tomography read is compared with the 2012 NIA-AA criteria.