Critical closing pressure in cerebrovascular circulation
Critical closing pressure in cerebrovascular circulation
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DOI：
10.1136/jnnp.66.5.606
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发表时间：
1999-05-01
影响因子：
11
通讯作者：
Pickard, JD
中科院分区：
文献类型：
--
作者：
Czosnyka, M;Smielewski, P;Pickard, JD
目的-脑临界闭合压（CCP）被定义为动脉压力阈值，低于该阈值动脉血管就会塌陷。假设这等于颅内压 (ICP) 加上脑动脉平滑肌活跃张力的贡献。评估颅脑损伤患者CCP与ICP、脑自动调节以及其他临床和血流动力学模式的相关性。方法-每天记录通气患者的颅内压、动脉血压(ABP)和大脑中动脉血流速度。处理波形以计算 CCP、经颅多普勒脑自动调节指数 (Mx)、平均动脉压 (ABP)、颅内压 (ICP) 和脑灌注压 (CPP)。 结果 - 临界闭合压反映了 ICP 在平台期和 B 波期间的时间相关变化。 CCP 和 ICP 之间的总体相关性轻微但显着（R=0.41；p
Objective-Cerebral critical closing pressure (CCP) has been defined as an arterial pressure threshold below which arterial vessels collapse. Hypothetically this is equal to intracranial pressure (ICP) plus the contribution from the active tone of cerebral arterial smooth muscle. The correlation of CCP with ICP, cerebral autoregulation, and other clinical and haemodynamic modalities in patients with head injury was evaluated.Method-intracranial pressure, arterial blood pressure (ABP) and middle cerebral artery blood flow velocity were recorded daily in ventilated patients. Waveforms were processed to calculate CCP, the transcranial Doppler-derived cerebral autoregulation index (Mx), mean arterial pressure (ABP), intracranial pressure (ICP), and cerebral perfusion pressure (CPP).Results-Critical closing pressure reflected the time related changes in ICP during plateau and B waves. Overall correlation between CCP and ICP was mild but significant (R=0.41; p