Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter.
Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter.
复制标题
结节性甲状腺肿药物代谢和转运基因的异常 DNA 甲基化
DOI：
10.1186/1756-6614-4-15
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发表时间：
2011-10-12
期刊：
影响因子：
2.2
通讯作者：
Ji M
中科院分区：
文献类型：
--
作者：
Zhang L;Shi J;Xu L;Shi B;Hou P;Ji M
药物代谢酶和转运蛋白基因在维持人体正常生命过程中起着重要作用。它们的紊乱或缺陷会导致各种疾病的发生和发展。目前，大多数研究都集中在这些基因的遗传变异，然而，在本研究中，我们分析了11个药物代谢和转运基因的启动子甲基化在一个队列中的结节性甲状腺肿和正常甲状腺组织甲基化特异性PCR（MSP）。我们的数据首次揭示了结节性甲状腺肿和正常甲状腺组织中药物代谢和转运基因的不同甲基化谱，特别是ABCB 4、CYP 1B1、CYP 24 A1和SLC 1A2。鉴于这些基因有助于各种疾病的发展和进展，如多药耐药性和肿瘤发生，这些表观遗传事件可能因此在结节性甲状腺肿的发病机制中发挥关键作用。
The genes encoding drug-metabolizing enzymes and transporters play an important role in maintaining the normal life processes of human body. Their disorder or defect will lead to the occurrence and development of various diseases. Currently, most of studies have focused on genetic variations in these genes, however, in the present study, we analyzed promoter methylation of 11 drug metabolism and transport genes in a cohort of nodular goiter and normal thyroid tissues using methylation-specific PCR (MSP). Our data first revealed a distinct methylation profiling in drug metabolism and transport genes between nodular goiter and normal thyroid tissues, particularlyABCB4,CYP1B1andCYP24A1andSLC1A2. Given these genes contribute to the development and progression of various diseases, such as multidrug resistance and tumorigenesis, these epigenetic events may thus play a critical role in the pathogenesis of nodular goiter.