Development of a 4-D digital mouse phantom for molecular imaging research
Development of a 4-D digital mouse phantom for molecular imaging research
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DOI：
10.1016/j.mibio.2004.03.002
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Berr, SS
中科院分区：
文献类型：
--
作者：
Segars, WP;Tsui, BMW;Berr, SS
目的：研制逼真、灵活的四维数字鼠标幻影，并探讨其在分子影像学研究中的应用价值。方法：基于高分辨率三维磁共振显微镜（MRM）数据，用非均匀有理b样条（NURBS）曲面建模器官形状。心脏和呼吸运动是基于从正常小鼠获得的门控磁共振成像（MRI）数据建模的。在单光子发射计算机断层扫描（SPELT）和x射线计算机断层扫描（CT）中进行了试点模拟研究，以证明幻像的实用性。结果：NURBS是一种高效灵活的方法，可以准确地模拟逼真的4-D数字小鼠幻影的解剖和心脏和呼吸运动。该模型能够产生真实的分子成像数据，从而对成像设备和技术进行评估。结论：幻影为分子成像研究提供了一种独特而有用的工具。它可以用于开发新的成像仪器、图像采集策略以及图像处理和重建方法。(C) 2004爱思唯尔公司版权所有。
PURPOSE: We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research.METHODS: Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained from normal mice. Pilot simulation studies in single-photon emission computed tomography (SPELT) and X-ray computed tomography (CT) were performed to demonstrate the utility of the phantom.RESULTS: NURBS are an efficient and flexible way to accurately model the anatomy and cardiac and respiratory motions for a realistic 4-D digital mouse phantom. The phantom is capable of producing realistic molecular imaging data from which imaging devices and techniques can be evaluated.CONCLUSION: The phantom provides a unique and useful tool in molecular imaging research. It can be used in the development of new imaging instrumentation, image acquisition strategies, and image processing and reconstruction methods. (C) 2004 Elsevier Inc. All rights reserved.