Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease
Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease
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DOI：
10.1111/1756-185x.12472
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发表时间：
2017-02-01
影响因子：
2.5
通讯作者：
Bhatia, Madhav
中科院分区：
文献类型：
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作者：
Muniraj, Nethaji;Stamp, Lisa K.;Bhatia, Madhav
目的：硫化氢(H_2S)是体内产生的一种气体介质。在实验模型中，内源性产生的硫化氢已被证明具有促炎作用。本研究的目的是研究类风湿性关节炎(RA)、痛风和骨关节炎(OA)这三种常见的风湿性疾病是否存在过氧化氢，并确定其水平是否与疾病活动性有关。取血浆，尽可能取滑液(SF)。结果：类风湿关节炎和痛风患者血浆中的SF-H_2S水平均显著高于相应的血浆水平。无论是类风湿性关节炎还是痛风患者，其血浆H_2S水平均与健康对照组无明显差异。在骨性关节炎患者中，血浆硫化氢水平显著高于健康对照组。在RA中，SF-H2S水平与疾病活动评分(DAS-28)和关节压痛计数相关。结论：关节中存在H2S，在风湿性疾病中起促炎介质作用。硫化氢可能是治疗这些疾病的新靶点。
Objective: Hydrogen sulfide (H2S) is a gaseous mediator produced in the body. In experimental models, endogenously produced H2S has been shown to have pro-inflammatory effects. The aim of this study was to investigate whether H2S is present in three common rheumatic diseases, rheumatoid arthritis (RA), gout and osteoarthritis (OA) and to determine if H2S levels correlate with disease activity.Methods: Patients with RA, gout, OA, and healthy controls (n = 30 each) were recruited. Plasma and where possible, synovial fluid (SF), were obtained. Levels of H2S and interleukin-6 (IL-6) (a known inflammatory marker as a positive control) were determined and assessed for their relationship with disease activity.Results: SF-H2S levels were significantly elevated in both RA and gout when compared to respective plasma levels. Plasma levels of H2S were not different from those in healthy controls in patients with either RA or gout. In OA, plasma levels of H2S were significantly elevated compared to healthy controls. In RA, SF-H2S levels correlated with Disease Activity Score (DAS)-28 and tender joint count.Conclusion: H2S is present in the joint and acts as a pro-inflammatory mediator in rheumatic diseases. H2S may be a novel therapeutic target for these conditions.