Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization
Chromosomal domains: epigenetic contexts and functional implications of genomic compartmentalization
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DOI：
10.1016/j.gde.2012.12.009
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发表时间：
2013-04-01
影响因子：
4
通讯作者：
Cavalli, Giacomo
中科院分区：
文献类型：
--
作者：
Tanay, Amos;Cavalli, Giacomo
我们回顾了在绘制染色体接触图谱方面的最新进展，并比较了在果蝇和哺乳动物细胞中关于染色体接触结构域组织的新见解。讨论了导致观察到Hi-C结构域的潜在场景以及它们与所涉及的染色体元素的表观基因组背景的关联。我们认为，尽管染色体区域划分的机制和精确的物理结构尚未完全解决，但它对基因组调控和基因组进化的影响是深远的。具体地说，我们假设结构域正在促进基因组区划，从而支持后生动物中复杂的、模块化的和组织特异性转录程序的实施。
We review recent developments in mapping chromosomal contacts and compare emerging insights on chromosomal contact domain organization in Drosophila and mammalian cells. Potential scenarios leading to the observation of Hi-C domains and their association with the epigenomic context of the chromosomal elements involved are discussed. We argue that even though the mechanisms and precise physical structure underlying chromosomal domain demarcation are yet to be fully resolved, the implications to genome regulation and genome evolution are profound. Specifically, we hypothesize that domains are facilitating genomic compartmentalization that support the implementation of complex, modular, and tissue specific transcriptional program in metazoa.