Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients
Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients
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DOI：
10.1038/s41467-020-16670-2
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发表时间：
2020-05-29
影响因子：
16.6
通讯作者：
Marimuthu, Kalisvar
中科院分区：
文献类型：
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作者：
Chia, Po Ying;Coleman, Kristen Kelli;Marimuthu, Kalisvar
了解SARS-CoV-2在空气中的颗粒大小分布和环境污染模式对于感染预防政策至关重要。在这里，我们从COVID-19患者的医院房间中筛选SARS-CoV-2 RNA的表面和空气样本。在ICU的3个空气传播感染隔离室（AIRs）和普通病房的27个AIRs中进行环境采样。共采集地表样品245个。56.7%的房间至少有一个环境表面受到污染。15名患者中有10名（66.7%）在患病第一周内显示出高触摸表面污染，3名（20%）在患病第一周后显示出高触摸表面污染（p = 0.01，卡方（2）检验）。在普通病房的27个AIRs中的3个进行了空气采样，并在两个房间中检测到尺寸>4 μ m和1-4 μ m的SARS-CoV-2 PCR阳性颗粒，尽管这些房间每小时换气12次。这保证了对SARS-CoV-2的空气传播潜力的进一步研究。
Understanding the particle size distribution in the air and patterns of environmental contamination of SARS-CoV-2 is essential for infection prevention policies. Here we screen surface and air samples from hospital rooms of COVID-19 patients for SARS-CoV-2 RNA. Environmental sampling is conducted in three airborne infection isolation rooms (AIIRs) in the ICU and 27 AIIRs in the general ward. 245 surface samples are collected. 56.7% of rooms have at least one environmental surface contaminated. High touch surface contamination is shown in ten (66.7%) out of 15 patients in the first week of illness, and three (20%) beyond the first week of illness (p = 0.01, chi(2) test). Air sampling is performed in three of the 27 AIIRs in the general ward, and detects SARS-CoV-2 PCR-positive particles of sizes >4 mu m and 1-4 mu m in two rooms, despite these rooms having 12 air changes per hour. This warrants further study of the airborne transmission potential of SARS-CoV-2.