Intramolecular decarboxylative coupling as the key step in copper-catalyzed domino reaction: facile access to 2-(1,3,4-oxadiazol-2-yl)aniline derivatives.
Intramolecular decarboxylative coupling as the key step in copper-catalyzed domino reaction: facile access to 2-(1,3,4-oxadiazol-2-yl)aniline derivatives.
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DOI：
10.1039/c5cc01116g
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发表时间：
2015-03
影响因子：
4.9
通讯作者：
Cheng Xu;Fengcheng Jia;Qun Cai;Dengke Li;Zhi-Wen Zhou;A. Wu
中科院分区：
文献类型：
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作者：
Cheng Xu;Fengcheng Jia;Qun Cai;Dengke Li;Zhi-Wen Zhou;A. Wu
以简单易得的靛红和酰肼为原料，发展了一种铜催化合成2-（1，3，4-恶二唑-2-基）苯胺衍生物的多米诺反应路线。这一多米诺过程综合了连续缩合、碱促开环和关键的铜催化脱羧偶联形成分子内C-O键。
A copper-catalyzed domino protocol for the synthesis of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives has been developed from simple and available isatins and hydrazides. This domino process integrated consecutive condensation, base-promoted ring-opening and the key copper-catalyzed decarboxylative coupling for intramolecular C-O bond formation.