Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.
Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.
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DOI：
10.1016/b978-0-12-385044-7.00005-9
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发表时间：
2010
影响因子：
--
通讯作者：
Cook TA
中科院分区：
文献类型：
--
作者：
Charlton-Perkins M;Cook TA
在过去，眼睛的结构，发育和生理学在整个动物王国中的巨大差异导致了广泛接受的观点，即眼睛是多系的，也就是说，它们在进化过程中独立出现了多次。尽管脊椎动物和无脊椎动物的眼睛不同，但越来越明显的是，这两个群体的眼睛发育在遗传水平上比以前假设的更相似，迫使人们重新审视眼睛的进化。在过去的25年里，了解果蝇眼睛发育过程中细胞类型特化的分子基础一直是许多实验室的研究重点，其中许多发现在第1章和第4章中得到了很好的回顾。然而，一个较少探索的研究领域，考虑了这些细胞一旦被指定，如何发育成功能性的眼部结构。本文综述了蝇眼视网膜、角膜透镜和色素上皮细胞终末分化的相关研究进展。此外，我们讨论了新出现的证据表明，不同的功能组件的苍蝇眼睛共享的发展途径和功能与脊椎动物的眼睛。
In the past, vast differences in ocular structure, development, and physiology throughout the animal kingdom led to the widely accepted notion that eyes are polyphyletic, that is, they have independently arisen multiple times during evolution. Despite the dissimilarity between vertebrate and invertebrate eyes, it is becoming increasingly evident that the development of the eye in both groups shares more similarity at the genetic level than was previously assumed, forcing a reexamination of eye evolution. Understanding the molecular underpinnings of cell type specification during Drosophila eye development has been a focus of research for many labs over the past 25 years, and many of these findings are nicely reviewed in Chapters 1 and 4. A somewhat less explored area of research, however, considers how these cells, once specified, develop into functional ocular structures. This review aims to summarize the current knowledge related to the terminal differentiation events of the retina, corneal lens, and pigmented epithelia in the fly eye. In addition, we discuss emerging evidence that the different functional components of the fly eye share developmental pathways and functions with the vertebrate eye.