Evaluation of reproductive parameters in adult male Wistar rats after subchronic exposure (gavage) to benomyl.
Evaluation of reproductive parameters in adult male Wistar rats after subchronic exposure (gavage) to benomyl.
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亚慢性暴露（灌胃）苯菌灵后成年雄性 Wistar 大鼠生殖参数的评估。
DOI：
10.1080/15287398809531210
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Juanita P. Diggs
中科院分区：
文献类型：
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作者：
Ralph E. Linder;G. Rehnberg;L. Strader;Juanita P. Diggs
经验证的饲养 102 日龄雄性 Wistar 大鼠每天灌胃 0、1、5、15 或 45 mg/kg.d 苯菌灵。 62天后将动物与未经处理的雌性交配，并在76-79天后处死，以评估选定的雄性生殖终点。在给予 45 mg/kg.d 的大鼠中观察到最小至中度的变化；这些包括睾丸和附睾重量减少、尾部精子储备减少、精子产量减少、断头精子数量增加以及含有多核巨细胞的生精小管数量增加。生殖性能、精囊和前列腺重量、精子活力、血清黄体生成素、卵泡刺激素、催乳素和雄激素结合蛋白均不受任何测试剂量的影响。根据这些终点，无作用水平为 15 mg/kg.d。
Proven-breeder 102-d-old male Wistar rats were gavaged daily with 0, 1, 5, 15, or 45 mg/kg.d benomyl. The animals were bred to untreated females after 62 d and killed after 76-79 d for evaluation of selected male reproductive end points. Minimal to moderate changes were observed in rats dosed with 45 mg/kg.d; these included decreased testis and epididymis weight, reduced cauda sperm reserves, decreased sperm production, increased numbers of decapitated spermatozoa, and increased numbers of seminiferous tubules containing multinucleated giant cells. Reproductive performance, seminal vesicle and prostate weight, sperm motility, serum luteinizing hormone, follicle-stimulating hormone, prolactin, and androgen binding protein were not affected by any of the dosages tested. Based on these end points, the no-effect level was 15 mg/kg.d.