Effects of endogenous and exogenous prostaglandin in neurotransmission in canine trachea.
Effects of endogenous and exogenous prostaglandin in neurotransmission in canine trachea.
复制标题
内源性和外源性前列腺素对犬气管神经传递的影响。
DOI：
--
复制
发表时间：
1987
影响因子：
2.1
通讯作者：
V. Sharma
中科院分区：
文献类型：
--
作者：
E. Daniel;C. Davis;V. Sharma
在单蔗糖间隙和器官浴中研究了PGE 2对去上皮犬气管条神经传递的影响。前列腺素E2是一种有效的抑制剂的启动兴奋性接点电位（ejps），只是次最大的神经刺激。浓度为10（-9）或10（-8）M的PGE 2几乎或完全消除它们。在相同的剂量范围内，PGE2在27摄氏度的蔗糖间隙或37摄氏度的肌肉浴中对场刺激的收缩反应也减少或消除;低频减少更大。对乙酰胆碱的反应也被抑制，但显着低于场刺激。这些与PGE2的主要突触前以及一些突触后抑制作用一致。没有证据表明内源性PGE2影响兴奋性连接电位和收缩;即在我们的条件下，它们稳定数小时，不受吲哚美辛10（-6）和10（-5）M的影响。刺激后增强的EJPS振幅，最大值在10秒，观察到，并成为更显着的后，第一EJP已显着减少或废除PGE2。这种增强作用不受吲哚美辛的影响。提示PGE 2抑制的突触前过程可能参与了这种增强作用。犬气管是一个有用的准备时，在这里使用的实验条件下研究花生四烯酸产品对神经传递的影响。
The effect of PGE2 on neurotransmission in the canine tracheal strip dissected free of epithelium was studied in the single sucrose gap and organ bath. PGE2 was a potent inhibitor of the initiation of excitatory junction potentials (ejps) by just submaximal nerve stimulation. In a concentration of 10(-9) or 10(-8) M PGE2 nearly or completely abolished them. Contractile responses to field stimulation in the sucrose gap at 27 degrees C or in muscle baths at 37 degrees C were also reduced or abolished by PGE2 in the same dose range; reductions were greater at low frequency. Responses to acetylcholine were also depressed but significantly less than to field stimulation. These are consistent with major presynaptic as well as some postsynaptic inhibitory actions of PGE2. No evidence was obtained that endogenous PGE2 affected excitatory junction potentials and contractions; i.e. they were stable for hours and unaffected by indomethacin 10(-6) and 10(-5) M under our conditions. Post-stimulus potentiation of ejps amplitude, maximum at 10 s, was observed and became more marked after the first ejp had been markedly reduced or abolished by PGE2. This potentiation was unaffected by indomethacin. It was suggested that a presynaptic process inhibited by PGE2 might participate in this potentiation. The canine trachea is a useful preparation when studied under the experimental condition used here for study of effects of products of arachidonate on neurotransmission.
吲哚美辛可以抑制狗的气道高反应性，但不能抑制臭氧引起的中性粒细胞流入。
DOI：
10.1164/arrd.1984.130.2.220
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
O'Byrne,PM;Walters,EH;Aizawa,H;Fabbri,LM;Holtzman,MJ;Nadel,JA
通讯作者：
Nadel,JA
犬臭氧暴露后气道高反应性和支气管肺泡灌洗液中细胞计数的变化。
DOI：
--
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Fabbri,LM;Aizawa,H;Alpert,SE;Walters,EH;O'Byrne,PM;Gold,BD;Nadel,JA;Holtzman,MJ
通讯作者：
Holtzman,MJ