Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues
Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues
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DOI：
10.1002/cbic.200800451
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发表时间：
2008-11-03
期刊：
影响因子：
3.2
通讯作者：
Fernandez, Jose M. Garcia
中科院分区：
文献类型：
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作者：
Aguilar, Matilde;Gloster, Tracey M.;Fernandez, Jose M. Garcia
1-脱氧-6-氧杂-N-（N′-辛基）硫代氨基甲酰基等中性的香花藤碱B2类似物是比天然生物碱更有效的β-葡萄糖苷酶抑制剂。对海栖热袍菌（Thermotoga maritima）GH-A β-葡萄糖苷酶家族的复合物的结构研究表明，该复合物与母体化合物的结合模式明显不同。
Neutral calystegine B2analogues, such as the 1-deoxy-6-oxa-N-(N′-octyl)thiocarbamoyl derivative, proved to be more potent β-glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH-A β-glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.