A near-infrared luminescent Mn2+-doped NaYF4:Yb,Tm/Fe3+ upconversion nanoparticles redox reaction system for the detection of GSH/Cys/AA
A near-infrared luminescent Mn2+-doped NaYF4:Yb,Tm/Fe3+ upconversion nanoparticles redox reaction system for the detection of GSH/Cys/AA
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近红外发光Mn2+掺杂NaYF4:Yb,Tm/Fe3上转换纳米粒子氧化还原反应体系用于检测GSH/Cys/AA
DOI：
10.1016/j.talanta.2017.05.031
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发表时间：
2017-09-01
期刊：
影响因子：
6.1
通讯作者：
Chen, Hongqi
中科院分区：
文献类型：
--
作者：
Zhang, Liping;Ling, Bo;Chen, Hongqi
建立了基于氧化还原反应的上转换发光法测定谷胱甘肽（GSH）、l -半胱氨酸（Cys）和l -抗坏血酸（AA）的方法。我们合成了聚丙烯酸（PAA）修饰的Mn2+掺杂的NaYF4:Yb，Tm上转换纳米粒子（UCNPs），由于这些UCNPs的羧基与Fe3+配合形成了UCNPs/Fe3+体系，这些UCNPs的发光被有效猝灭。GSH、Cys或AA将Fe3+还原为Fe2+，诱导了UCNPs的发光恢复。在优化条件下，GSH、Cys和AA的线性浓度范围分别为0.25 ~ 300 μ M、0.5 ~ 875 μ M和0.5 ~ 350 μ M，检测限（3 S/K）分别为0.2 μ M、0.5 μ M和0.2 μ M。因此，UCNPs/Fe3+系统成功应用于GSH、Cys或AA的传感。
An upconversion luminescence method was developed for the determination of glutathione (GSH), L-cysteine (Cys) or L-ascorbic acid (AA) based on redox reaction. We synthesized poly(acrylic acid) (PAA)-modified Mn2+-doped NaYF4:Yb,Tm upconversion nanoparticles (UCNPs), and the luminescence of these UCNPs was effectively quenched due to their carboxyl groups coordinating with Fe3+ to form a UCNPs/Fe3+ system. GSH, Cys or AA reduced Fe3+ to Fe2+, which induced the luminescence recovery of the UCNPs. Under the optimized conditions, wide linear concentration ranges from 0.25-300 mu M for GSH, 0.5-875 mu M for Cys and 0.5-350 mu M for AA were found, and the detection limits (3 S/K) were 0.2 mu M, 0.5 mu M and 0.2 mu M, respectively. Thus, the UCNPs/Fe3+ system was successfully applied for sensing GSH, Cys or AA.