Arrestin regulation of small GTPases.
Arrestin regulation of small GTPases.
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小 GTP 酶的抑制蛋白调节。
DOI：
10.1007/978-3-642-41199-1_19
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发表时间：
2014
影响因子：
--
通讯作者：
Cameron RT
中科院分区：
文献类型：
--
作者：
Cameron RT
通过阻滞蛋白调控小gtpase是一种相对较新的方式，通过阻滞蛋白可以对细胞信号级联施加影响，因此，分子相互作用和特定的结合伙伴仍在被发现。β-阻滞素调控GTPase活性的途径于2001年首次被阐明。自这项最初的研究以来，越来越多的证据表明，通过直接相互作用和通过GTPase调节蛋白的支架来抑制GTPase活性的调节。考虑到小gtpase在多种基本细胞功能中的重要性，对这一途径的药理学操作可能代表了一个具有治疗潜力的领域，特别是在癌症病理和心脏肥厚方面。通过阻滞蛋白调控小gtpase是一种相对较新的方式，通过阻滞蛋白可以对细胞信号级联施加影响，因此，分子相互作用和特定的结合伙伴仍在被发现。β-阻滞素调控GTPase活性的途径于2001年首次被阐明。自这项原始研究以来，越来越多的证据表明，通过直接相互作用和通过GTPase调节蛋白的支架来抑制GTPase活性的调节。考虑到小gtpase在多种基本细胞功能中的重要性，对这一途径的药理学操作可能代表了一个具有治疗潜力的领域，特别是在癌症病理和心脏肥厚方面。
The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001. Since this original study, growing evidence has emerged for arrestin modulation of GTPase activity through direct interactions and also via the scaffolding of GTPase regulatory proteins. Given the importance of small GTPases in a variety of essential cellular functions, pharmacological manipulation of this pathway may represent an area with therapeutic potential, particularly with respect to cancer pathology and cardiac hypertrophy.The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001. Since this original study, growing evidence has emerged for arrestin modulation of GTPase activity through direct interactions and also via the scaffolding of GTPase regulatory proteins. Given the importance of small GTPases in a variety of essential cellular functions, pharmacological manipulation of this pathway may represent an area with therapeutic potential, particularly with respect to cancer pathology and cardiac hypertrophy.
Mek 和 p38 MAPK 依赖性途径参与白细胞介素 6 对大鼠 MtT/S 生长激素细胞中人类生长激素基因表达的积极影响。
DOI：
10.1016/s1001-9294(09)60016-x
发表时间：
2008
期刊：
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
影响因子：
--
作者：
F. Gong;Jie;Yi
通讯作者：
Yi