Characterization of eosinophilic hyaline droplets in schwannoma
Characterization of eosinophilic hyaline droplets in schwannoma
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DOI：
10.1007/s00401-002-0631-8
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发表时间：
2003-02-01
影响因子：
12.7
通讯作者：
Nakazato, Y
中科院分区：
文献类型：
--
作者：
Yokoo, H;Arai, H;Nakazato, Y
在神经鞘瘤中，常见的脱色结构，如奇异的核深染、脂褐素沉积、出血、水肿等，被认为是肿瘤良性性质的标志。透明小球或嗜酸性透明小滴(EHD)广泛存在于多种肿瘤中，但它们是神经鞘瘤罕见的组织学表现，其细节尚不清楚。我们复习了171例传统组织学诊断的神经鞘瘤。按发生部位分类：听神经43条，其他脑神经9条，脊神经根30条，软组织89条。EHD8/43例，1/9例，1/30例，2/89例。液滴位于核膜和突起内。超微结构为电子致密、圆形至卵圆形细胞器，与次生溶酶体难以区分。小滴细胞的MIB-1免疫标记几乎为阴性；然而，它们保持了存活的核外观，没有核破裂、固缩或凋亡改变。因此，我们得出结论，EHD是神经鞘瘤退行性结构的新成员，也是低生长潜力的标志。此外，它们在听神经瘤中的较高频率可能表明它们与其他部位起源的神经鞘瘤具有不同的性质。还讨论了EHD与细胞衰老的可能相关性。
In schwannoma, degerierative structures, such as bizarre hyperchromatic nuclei, lipofuscin deposition, hemorrhage, edema, etc., are frequently encountered and are regarded as hallmarks of the benign nature of the neoplasm. Hyaline globules or eosinophilic hyaline droplets (EHDs) have been observed in a large variety of tumors, but they are rare histological manifestations of schwannoma, and the details have not been described as yet. We reviewed 171 cases of schwannoma of conventional histology. We classified them based on the sites where they occurred as follows: 43 acoustic nerves, 9 other cranial nerves, 30 spinal nerve roots, and 89 soft parts. We found EHDs in 8/43, 1/9, 1/30, 2/89 cases, respectively. The droplets were located in both the perikarya and processes. Ultrastructurally, they were electron-dense, round to ovoid organelles, and indistinguishable from secondary lysosomes. MIB-1 immunolabeling of the droplet-bearing cells was almost negative; however, they maintained a viable nuclear appearance without karyorrhexis, pyknosis or apoptotic changes. We therefore conclude that EHD is a new member of degenerative structures in schwannoma, and a hallmark of low growth potential. Furthermore, their higher frequency in acoustic schwannoma may suggest their distinct nature from those originated in the other sites. Possible relevance of EHDs and cellular senescence is also discussed.