Global Research Status and Trends in Hair Follicle Stem Cells: a Bibliometric Analysis
Global Research Status and Trends in Hair Follicle Stem Cells: a Bibliometric Analysis
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DOI：
10.1007/s12015-022-10404-1
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发表时间：
2022-07
影响因子：
4.8
通讯作者：
C. Dong;Jing Du;Zhou Yu;Xianjie I. Ma
中科院分区：
文献类型：
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作者：
C. Dong;Jing Du;Zhou Yu;Xianjie I. Ma
背景毛囊干细胞来源于毛囊隆突区，是重要的自体干细胞来源。文献计量学是一种对某一专题的研究论文进行定量分析的统计方法。本研究旨在通过文献计量学分析，估计全球HFSCs的研究现状和趋势。系统评估了按国家/地区、机构、期刊和作者分层的出版物分布。关键字的频率进行了评估，并采用文献计量映射来描述HFSC research.ResultsA的发展，符合我们的筛选标准，共458篇出版物，包括在这项研究中，423（92.4%）的文章和35（7.6%）的评论。美利坚合众国（USA）在146篇（31.9%）出版物数量方面排名第一，其次是中国，为130篇（28.4%），这与H指数的排名一致。作者关键词可分为基础研究、应用研究和生物标志物3类，应用研究类的关键词平均发表时间晚于基础研究类。在基础研究中，关键词“凸起”、“巢蛋白”和“皮肤”是前三个最常见的关键词;在应用研究中，关键词“分化”、“增殖”和“脱发”是前三个最常见的关键词。在最新的研究热点中，“细胞凋亡”和“组织工程”是比较新的关键词。关键词研究的重点逐渐从基础研究转向应用研究。HFSCs的分化增殖及其在脱发发病中的作用是近年来的研究热点。细胞凋亡和组织工程是目前研究的热点。我们的研究为HFSC的研究历史、现状和未来趋势提供了深刻的见解。图形摘要
BackgroundHair follicle stem cells (HFSCs) are derived from the bulge region and are important autologous stem cell sources. Bibliometric is a statistical method that quantitatively analyses the research papers concerned about one special topic. This study aims to estimate the research status and trends of HFSCs worldwide by bibliometric analyses.MethodsData were obtained from the Web of Science by searching keywords related to HFSCs. Publication distributions stratified by countries/regions, institutions, journals, and authors were systematically assessed. The frequency of keywords was assessed, and bibliometric mapping was employed to describe the development of HFSC research.ResultsA total of 458 publications that met our screening criteria were included in this study, consisting of 423 (92.4%) articles and 35 (7.6%) reviews. The United States of America (USA) ranked first in the number of publications at 146 (31.9%), followed by China at 130 (28.4%), which is consistent with the rank of the H-index. Author keywords were classified into three clusters, namely, basic study, applied study, and biomarker; average publication time of keywords in applied study cluster is later than basic study cluster. The keywords “bulge”, “nestin”, and “skin” are the top three most frequent keywords in basic studies; “differentiation”, “proliferation”, and “alopecia” are the top three most frequent keywords in applied studies. With respect to the latest research hotspots, “apoptosis” and “tissue engineering” are relatively new keywords.ConclusionsThe USA and China were the most productive countries for research on HFSCs. The focus of keywords gradually shifted from basic study to applied study. Research on the differentiation/proliferation of HFSCs and the role of HFSCs in alopecia have been recent research focuses. Apoptosis and tissue engineering are recommended as promising research hotspots. Our study provides profound insights into the research history, current status, and future trend of HFSCs.Graphical abstract