Coagulation, Flocculation, and Denaturation: A Century of Research into Protoplasmic Theories of Anesthesia
Coagulation, Flocculation, and Denaturation: A Century of Research into Protoplasmic Theories of Anesthesia
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凝固、絮凝和变性：一个世纪的麻醉原生质理论研究
DOI：
10.1213/ane.0000000000000287
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发表时间：
2014
影响因子：
5.7
通讯作者：
M. Perouansky
中科院分区：
文献类型：
--
作者：
M. Perouansky
在麻醉发现后的二十年内，出现了胶体的物理化学概念和原生质的生物学概念。将这些概念融合到一个理论框架中，这个框架在几十年前基本上被遗忘了，它有望揭示基本的生物学真理，并在“以太日”之后的世纪里确定对麻醉机制的研究。19世纪70年代，对未染色组织中光学变化的观察被浓缩成一种通过原生质凝固来麻醉的理论。基本的假设，原生质内蛋白质的构象变化导致麻醉的所有行为效应，一直持续到20世纪。目的是在基本的细胞生物学框架内使用物理化学来解释麻醉。在脂质膜霸权的几十年里，这一庞大的工作被搁置一边，即使在可兴奋膜中的蛋白质被牢固地确立为即时麻醉作用的介质之后，也仍然默默无闻。这篇文章是一个长期的跨学科的研究努力致力于“原生质理论”的时候，注意力越来越多地指向检查（无）意识的性质和非规范的麻醉暴露的后果，不容易占传统的药理学概念的提醒。
Within two decades of the discovery of anesthesia, the physicochemical concept of colloid and the biological concept of protoplasm had emerged. Fusion of these concepts into a theoretical framework, which has been largely forgotten decades ago, promised to uncover fundamental biological truths and determined research into anesthetic mechanisms for a century after “Ether Day.” Observations of optical changes in unstained tissue were condensed into a theory of anesthesia by coagulation of protoplasm in the 1870s. The underlying hypotheses, conformational changes of proteins within the protoplasm cause all behavioral effects of anesthesia, continued to be pursued well into the 20th century. The goal was to explain anesthesia using physical chemistry within a fundamental cell biological framework. This large body of work, swept aside during the decades of lipid membrane hegemony, has remained in obscurity even after proteins in excitable membranes became firmly established as mediators of the immediate anesthetic effects. This article is a reminder of the prolonged interdisciplinary research effort dedicated to “protoplasmic theories” at a time when attention is increasingly directed toward examining the nature of (un)consciousness well as noncanonical consequences of anesthetic exposure that are not easily accounted for within conventional pharmacological concepts.
影响因子：
9.8
作者：
Culley, D. J.;Cotran, E. K.;Crosby, G.
通讯作者：
Crosby, G.
麻醉剂与膜-水界面的相互作用。
影响因子：
2.3
作者：
Pohorille,A;Cieplak,P;Wilson,MA
通讯作者：
Wilson,MA
结合的挥发性全身麻醉剂会改变局部蛋白质动力学和整体蛋白质稳定性。
影响因子：
8.8
作者：
Johansson,JS;Zou,H;Tanner,JW
通讯作者：
Tanner,JW