T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.
T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.
复制标题
T 细胞是宿主针对马来布鲁菌的保护所必需的，但不需要产生或响应白细胞介素 4。
DOI：
10.1128/iai.71.6.3097-3106.2003
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发表时间：
2003
影响因子：
3.1
通讯作者：
Rajan,TV
中科院分区：
文献类型：
--
作者：
Spencer,L;Shultz,L;Rajan,TV
T cells are known to be required for host protection in mouse models ofBrugia malayiinfection. Several independent studies in murine models have also highlighted the rapid induction of Th2-like responses after infection withB. malayiorB. pahangi. Previous data from our laboratory have described a significant increase in permissiveness in the absence of interleukin-4 (IL-4), the “prototypical” Th2 cytokine, involved in both the induction and maintenance of Th2 responses. These observations led to our hypothesis that T cells involved in murine host protection would respond to IL-4 signaling and differentiate into cells of the “type 2” phenotype. As such, these cells would presumably also act as major sources of IL-4. To investigate these hypotheses, we performed several adoptive transfers in which we controlled the cell population(s) able to produce or respond to IL-4. We show here that, in contrast to our original hypotheses, IL-4 production and IL-4 receptor expression by T cells are both dispensable for T-cell-mediated host protection. Instead, our data imply that T cells may be required for eosinophil accumulation at the site of infection.
