THYROID-FUNCTION IN PATIENTS WITH BREAST-CANCER
THYROID-FUNCTION IN PATIENTS WITH BREAST-CANCER
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DOI：
10.1016/0277-5379(87)90319-1
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发表时间：
1987-05-01
期刊：
影响因子：
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通讯作者：
HOIERMADSEN, M
中科院分区：
文献类型：
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作者：
RASMUSSON, B;FELDTRASMUSSEN, U;HOIERMADSEN, M
对58例乳腺癌患者的甲状腺功能进行了评估，并与年龄匹配的健康女性对照组的数据进行了比较。29例患者（50%）存在低水平甲状腺抗体：21例患者（36%）存在低活性甲状腺刺激抗体。甲状腺球蛋白抗体阳性者10例（17%），对照组3例（P < 0.05）。10例甲状腺球蛋白抗体患者中有9例同时存在微粒体抗体。两名患者仅具有微粒体抗体。另外还检测了10种自身免疫抗体。然而，这些在血清中要么不存在，要么以低浓度存在。独立于疾病的阶段，患者和对照组之间的血清三碘甲状腺原氨酸，甲状腺素，游离T3指数，游离T4指数，促甲状腺激素和甲状腺珠蛋白水平没有显着差异。总之，我们发现甲状腺功能正常的乳腺癌患者与健康对照组相比，甲状腺自身抗体的频率增加，这表明这种疾病和自身免疫性甲状腺疾病之间可能存在联系。
Thyroid function was evaluated in 58 patients with breast cancer and compared with data obtained from an age-matched control group of healthy women. Thyroid antibodies at low levels were present in 29 patients (50%): 21 patients (36%) had thyroid stimulating antibodies at low activity. Ten patients (17%) had thyroglobulin antibodies compared with 3 in the control group (P < 0.05). Nine of 10 patients with thyroglobulin antibodies had microsomal antibodies as well. Two patients had only microsomal antibodies. Additionally 10 autoimmune antibodies were determined. These were, however, either absent or present in low concentrations in serum. Independent of the stage of disease, no differences were demonstrated betwen patients and controls in serum levels of triiodothyronine, thyroxine, free T3 index, free T4 index, thyroid stimulating hormone, and thyroglobin. In conclusion, we found an increased frequency of thyroid autoantibodies in euthyroid patients with breast cancer compared with healthy controls suggesting a possible relation between this disease and autoimmune thyroid disease.