Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp SCSIO XWS03F03
Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp SCSIO XWS03F03
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Aspergchromones A 和 B，两种来自海洋海绵相关真菌 Aspergillus sp SCSIO XWS03F03 的新型聚酮化合物
DOI：
10.1080/10286020.2016.1231673
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发表时间：
2017
影响因子：
1.7
通讯作者：
Xu Shi-Hai
中科院分区：
文献类型：
--
作者：
Wang Ying;Lin Xiu-Ping;Ju Zhi-Ran;Liao Xiao-Jian;Huang Xiao-Jun;Zhang Chen;Zhao Bing-Xin;Xu Shi-Hai
从海洋海绵真菌gillussp的乙酸乙酯提取物中分离得到两个新的聚酮化合物：曲霉色酮A（1）和B（2），以及5个已知化合物：裂酮酸D（3），去甲芸香苷元（4），（3S）-5-羟基美莱因（5），（4S）-6-羟基异奥斯卡酮（6）和（-）-regiolone（7）。SCSIO XWS 03F03.通过光谱技术（1D和2D NMR、MS、UV和IR）鉴定了它们的结构。通过电子捕获密度（ECD）计算确定了新化合物的绝对构型。化合物3显示出中等的抗菌活性。
Two new polyketides, aspergchromones A (1) and B (2), together with five known compounds, secalonic acid D (3), noreugenin (4), (3S)-5-hydroxymellein (5), (4S)-6-hydroxyisosclerone (6), and (-)-regiolone (7), were isolated from the ethyl acetate extract of marine sponge-derived fungusAspergillussp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound3showed moderate antimicrobial activity.