Cx36 involvement in insulin secretion: characteristics and mechanism.
Cx36 involvement in insulin secretion: characteristics and mechanism.
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Cx36 参与胰岛素分泌：特征和机制。
DOI：
10.1080/cac.10.4-6.431.435
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发表时间：
2003
影响因子：
--
通讯作者：
Meda,Paolo
中科院分区：
文献类型：
--
作者：
Meda,Paolo
间隙连接连接产生胰岛素的胰腺β细胞。为了研究它们的功能，我们首先确定这些连接是由Cx36构成的。我们随后测试了改变Cx36和其他连接蛋白异构体表达的效果，并发现Cx36调节胰岛素分泌。鉴于胞质Ca2+在这种分泌中的突出作用，我们已经监测了这种阳离子，并发现它的处理在缺乏Cx36的胰岛素生成细胞群体中发生了改变。这些数据确定了Cx36与导致胰岛素分泌的刺激分泌途径之间的第一个分子联系。
Gap junctions connect the pancreatic β-cells which produce insulin. To investigate their function, we have first determined that these junctions are made of Cx36. We have then tested the effect of changing the expression of Cx36, and other connexin isoforms, and have found that Cx36 modulates insulin secretion. In view of the prominent role of cytosolic Ca2+in this secretion, we have monitored this cation, and have found that its handling is altered in populations of insulin-producing cells lacking Cx36. The data identify a first molecular link between Cx36 and the stimulus-secretion pathway leading to insulin secretion.