STUDY OF FACTORS THAT INFLUENCE THE CLINICAL-RESPONSE TO CIGUATERA FISH POISONING
STUDY OF FACTORS THAT INFLUENCE THE CLINICAL-RESPONSE TO CIGUATERA FISH POISONING
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DOI：
10.1016/0041-0101(93)90130-b
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发表时间：
1993-09-01
期刊：
影响因子：
2.8
通讯作者：
MARTIN, PMV
中科院分区：
文献类型：
--
作者：
GLAZIOU, P;MARTIN, PMV
在法属波利尼西亚对所有雪卡毒鱼中毒通报病例的标准化医疗记录进行了为期1年的观察性研究。目的是确定影响雪卡毒素鱼中毒临床反应的因素。在1991年期间，有551例病例由医生在标准化编码表上通报（通报率为每100，000人276例）。平均年龄36.6岁（S.D. 15.6）。最大的年龄组是30至49岁（每10万人中有562人）。性别比（男/女）为1.6。在551例病例中，257例（47%）有既往发作史。计算临床评分以评估每个病例的结果。当摄入的鱼是肉食性的（OR = 1.62，P = 0.02），当报告有既往发作史（OR = 1.71，P = 0.006）时，严重疾病的校正比值比（OR）（33%，评分大于5）显著增加。多次发病的严重程度增加，以及呈报率随年龄而增加，显示毒素可能在人体内积聚。
A 1-year observational study of all standardized medical records of ciguatera fish poisoning notified cases was conducted in French Polynesia. The objective was to determine the factors that influence the clinical response to ciguatera fish poisoning. During the year 1991, there were 551 cases notified on standardized code sheets by physicians (notification rate 276 per 100,000). The mean age was 36.6 years (S.D. 15.6). The largest age group was that between 30 and 49 years old (notification rate 562 per 100,000). The gender ratio (M/F) was 1.6. Of the 551 cases, 257 (47%) presented with a history of a previous attack. A clinical score was calculated to assess the outcome for each case. The adjusted odds ratio (OR) for a severe disease (33% with a score greater than 5) was significantly increased when the fish ingested was carnivorous (OR = 1.62, P = 0.02) and when a history of a previous attack was reported (OR = 1.71, P = 0.006). The increased severity of multiple episodes and the increase of the notification rate with age suggest a possible accumulation of toxin in the human organism.