Increased presynaptic dopamine function in Asperger syndrome
Increased presynaptic dopamine function in Asperger syndrome
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DOI：
10.1097/00001756-200404090-00003
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发表时间：
2004-04-09
期刊：
影响因子：
1.7
通讯作者：
von Wendt, LO
中科院分区：
文献类型：
--
作者：
Nieminen-von Wendt, TS;Metsähonkala, L;von Wendt, LO
阿斯伯格综合征的病因基本上是未知的，但多巴胺系统的异常已显示在临床重叠障碍。本研究旨在探讨突触前多巴胺在阿斯伯格综合征中的功能。以6-[F-18]氟-左旋多巴（[F-18]FDOPA）为示踪剂，对8名健康、无药物的阿斯伯格综合征男性和5名健康男性对照进行正电子发射断层扫描。在阿斯伯格综合征组，纹状体即壳核、尾状核和额叶皮层的[F-18]FDOPA内流（Ki）值升高。结果表明，阿斯伯格综合症患者的多巴胺系统受到影响。在精神分裂症中也获得了部分类似的结果，这表明不仅在临床特征上而且在发病机制上都有重叠。
The etiology of Asperger syndrome is essentially unknown, but abnormality of the dopamine system has been shown in clinically overlapping disorders. The present study was designed to investigate the presynaptic dopamine function in Asperger syndrome. Eight healthy, drug-free males with Asperger syndrome and five healthy male controls were examined with positron emission tomography using 6-[F-18]fluoro-L-DOPA ([F-18]FDOPA) as a tracer. In the Asperger syndrome group, the [F-18]FDOPA influx (Ki) values were increased in the striatum, i.e. in the putamen and caudate nucleus and in the frontal cortex. The results indicate that the dopamine system is affected in subjects with Asperger syndrome. Partially similar results have also been obtained in schizophrenia, suggesting an overlap not only of the clinical features but also of pathogenesis.