Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis
Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis
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DOI：
10.1542/peds.2010-3054
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发表时间：
2011-06-01
期刊：
影响因子：
8
通讯作者：
Bont, Louis
中科院分区：
文献类型：
--
作者：
Belderbos, Mirjam E.;Houben, Michiel L.;Bont, Louis
背景：呼吸道合胞病毒（RSV）是引起婴儿严重下呼吸道感染（LRTI）的最重要病原体。流行病学和基础研究表明，维生素 D 可以预防 RSV LRTI。目的：确定出生时血浆维生素 D 浓度与随后的 RSV LRTI 风险之间的关联。设计：在健康足月新生儿中进行了一项前瞻性出生队列研究。脐带血浆中 25-羟基维生素 D (25-OHD) 的浓度与出生后第一年的 RSV LRTI 相关，定义为每日日志中父母报告的 LRTI 症状以及鼻咽样本中同时存在 RSV RNA。 结果：研究人群包括 156 名新生儿。十八人 (12%) 感染了 RSV LRTI。平均血浆 25-OHD 浓度为 82 nmol/L。总体而言，27% 的新生儿体内有 25-OHD 浓度
BACKGROUND: Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI.OBJECTIVE: To determine the association between plasma vitamin D concentrations at birth and the subsequent risk of RSV LRTI.DESIGN: A prospective birth cohort study was performed in healthy term neonates. Concentrations of 25-hydroxyvitamin D (25-OHD) in cord blood plasma were related to RSV LRTI in the first year of life, defined as parent-reported LRTI symptoms in a daily log and simultaneous presence of RSV RNA in a nose-throat specimen.RESULTS: The study population included 156 neonates. Eighteen (12%) developed RSV LRTI. The mean plasma 25-OHD concentration was 82 nmol/L. Overall, 27% of neonates had 25-OHD concentrations