STUDIES OF ENDOTOXIN-INDUCED DECREASE IN LIPOPROTEIN-LIPASE ACTIVITY
STUDIES OF ENDOTOXIN-INDUCED DECREASE IN LIPOPROTEIN-LIPASE ACTIVITY
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DOI：
10.1084/jem.154.3.631
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发表时间：
1981-01-01
影响因子：
15.3
通讯作者：
CERAMI, A
中科院分区：
文献类型：
--
作者：
KAWAKAMI, M;CERAMI, A
由于甘油三酯从循环中的清除受损，各种侵入性刺激会导致高脂血症。研究了内毒素引起甘油三酯代谢关键酶--脂蛋白脂酶(LPL)活性降低的机制。在内毒素敏感的C3H/HEN小鼠中，注射内毒素16h后，脂肪组织中LPL活性明显受到抑制。内毒素耐药的C3H/HeJ小鼠对内毒素抑制LPL活性的作用不敏感。在注射内毒素后2小时，在C3H/HEN小鼠血液中检测到一种可转移因子，使C3H/HeJ小鼠和C3H/HEN小鼠的脂肪组织LPL活性受到抑制。内毒素孵育的C3H/HEN小鼠腹膜渗出细胞的条件培养液也能抑制C3H/HeJ小鼠的脂肪组织LPL。显然，渗出细胞对内毒素的反应是产生一种体液因子，抑制脂肪组织的LPL。
A variety of invasive stimuli induce hyperlipidemia due to impaired removal of triglyceride from the circulation. The mechanism by which endotoxin [from Escherichia coli] induces a deficiency in the activity of the key enzyme of triglyceride metabolism, lipoprotein lipase (LPL), was studied. In C3H/HeN (endotoxin-sensitive) mice, LPL activity in adipose tissue was markedly suppressed 16 h after endotoxin administration. Entotoxin-resistant C3H/HeJ mice were less sensitive to the suppressive effect of endotoxin of LPL activity. A transferable factor, detected in the blood of C3H/HeN mice 2 h after endotoxin injection, causes a suppression of adipose tissue LPL activity in C3H/HeJ mice and in C3H/HeN mice. Conditioned medium from the cultures of peritoneal exudate cells of C3H/HeN mice incubated in endotoxin also suppresses adipose tissue LPL in C3H/HeJ mice. Evidently, in response to endotoxin, exudate cells produce a humoral factor which suppresses adipose tissue LPL.