Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop
Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop
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DOI：
10.2174/1570162x18666191223114019
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发表时间：
2020-01-01
影响因子：
1
通讯作者：
Wahl, Angela
中科院分区：
文献类型：
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作者：
Akkina, Ramesh;Barber, Daniel L.;Wahl, Angela
与体外研究相比，传染病动物模型的主要优点是可以加深对免疫系统和病原体之间复杂动态的理解。虽然小动物模型比大型动物模型具有实际优势，但了解它们的局限性至关重要。尽管小动物模型至少需要对所研究的病原体敏感才能获得有意义的数据，但与人类相比，也应该反映发病机制的关键要素。此外，精心设计的艾滋病毒、肝炎病毒和结核病小动物模型还需要彻底了解人类和小动物之间免疫反应的异同，并应将这些知识纳入研究目标。为了讨论这些考虑因素，NIAID 于 2019 年 5 月 30 日主办了一场关于“艾滋病毒、乙型肝炎和结核病的小动物模型”的研讨会。研讨会的要点概述如下。
The main advantage of animal models of infectious diseases over in vitro studies is the gain in the understanding of the complex dynamics between the immune system and the pathogen. While small animal models have practical advantages over large animal models, it is crucial to be aware of their limitations. Although the small animal model at least needs to be susceptible to the pathogen under study to obtain meaningful data, key elements of pathogenesis should also be reflected when compared to humans. Well-designed small animal models for HIV, hepatitis viruses and tuberculosis require, additionally, a thorough understanding of the similarities and differences in the immune responses between humans and small animals and should incorporate that knowledge into the goals of the study. To discuss these considerations, the NIAID hosted a workshop on 'Small Animal Models for HIV, Hepatitis B, and Tuberculosis' on May 30, 2019. Highlights of the workshop are outlined below.