Role of prostaglandins in renin secretion.
Role of prostaglandins in renin secretion.
复制标题
前列腺素在肾素分泌中的作用。
DOI：
10.1038/ki.1981.86
复制
发表时间：
1981
影响因子：
19.6
通讯作者：
W. Henrich
中科院分区：
文献类型：
--
作者：
W. Henrich
The ability of the renal prostaglandin (PG) system to enhance renin secretion remains a subject of intense investigative interest and some controversy. Earlier studies had isolated several factors that could independently alter renin release: specifically, a decrease in renal perfusion pressure, the sympathetic nervous system, or alterations in sodium delivery to or transport at the macula densa were identified as important stimuli for renin release [1]. The subsequent demonstration that several PG's are capable of independently stimulating renin secretion has generated numerous recent investigations that probe the relative potency of the different PG's to stimulate renin release. Moreover, the importance of PG's for the function of other known renin secretion stimuli (such as the arterial baroreceptor) has also been examined. This review highlights two distinct areas of the prostaglandin-renin interaction: (1) PG's as primary stimuli for renin release; and (2) PG's as integral cofactors for other stimuli to induce the juxtaglomerular cells to release renin. The relative potency of each of these stimuli will also be considered, and areas of the relationship between PG's and renin that particularly merit further clarification will be emphasized.
