Mass spectra of Sceletium alkaloids
Mass spectra of Sceletium alkaloids
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Sceletium 生物碱的质谱
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
P. W. Jeffs
中科院分区：
文献类型：
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作者：
N. H. Martin;D. Rosenthal;P. W. Jeffs
已经对几种天然存在的 Sceletium 生物碱以及几种合成变体的质谱进行了研究。使用的技术包括高分辨率质量测量、通过离子散焦技术和特定氘标记与低分辨率质谱相结合的亚稳态跃迁分析。已确定了所研究的四种基本结构类型的特征性主要断裂途径：顺式-3a-芳基-八氢吲哚环系统，以 mesembrine 为例；其 2,3-吡啶并类似物，Sceletium A4；以tortuosamine为代表的seco系列吡啶碱；以及以tortuosamine为代表的mesembrine型seco类似物；以及以脱氢Joubertiamine为代表的mesembrine型seco类似物。
The mass spectra of several naturally occuring Sceletium alkaloids, as well as several synthetic variants, have been investigated. Techniques used include high resolution mass measurements, analysis of metastable transitions by the technique of ion defocusing and specific deuterium labeling in conjunction with low resolution mass spectrometry. Characteristic major fragmentation pathways have been determined for four basic structure types studied: the cis-3a-aryl-octahydroindole ring system, exemplified by mesembrine; its 2,3-pyrido analog, Sceletium A4; the seco series of pyridine bases, represented by tortuosamine; and the seco analog of the mesembrine-type represented by tortuosamine; and the seco analog of the mesembrine-type represented by dehydrojoubertiamine.