Diets high in monounsaturated and polyunsaturated fatty acids decrease fatty acid synthase protein levels in adipose tissue but do not alter other markers of adipose function and inflammation in diet-induced obese rats
Diets high in monounsaturated and polyunsaturated fatty acids decrease fatty acid synthase protein levels in adipose tissue but do not alter other markers of adipose function and inflammation in diet-induced obese rats
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DOI：
10.1016/j.plefa.2013.12.002
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发表时间：
2014-02-01
影响因子：
3
通讯作者：
Taylor, Carla G.
中科院分区：
文献类型：
--
作者：
Enns, Jennifer E.;Hanke, Danielle;Taylor, Carla G.
本研究调查了来自不同脂肪来源的单不饱和脂肪酸和多不饱和脂肪酸（高油酸油菜籽、油菜籽、油菜籽-亚麻籽（3：1混合物）、红花或大豆油，或猪油饮食）对喂食高脂肪（55%能量）饮食12周的肥胖倾向大鼠的脂肪组织功能和炎症标志物的影响。脂肪组织脂肪酸组成反映了膳食脂肪酸组成。与猪油组相比，所有组的脂肪组织中脂肪酸合酶的蛋白质水平均较低，但mRNA水平不低。脂联素和脂肪酸受体GPR 41和GPR 43蛋白水平也发生了变化，但脂肪组织和血清中的其他代谢和炎症介质在各组之间没有变化。总体而言，大鼠喂养植物油或猪油为基础的高脂肪饮食似乎是在很大程度上抵抗主要的表型变化时，膳食脂肪组成的改变，提供一个高脂肪饮食的背景下，特定的脂肪酸谱的重要性几乎没有支持。(C)2013爱思唯尔有限公司版权所有。
This study investigates the effects of monounsaturated and polyunsaturated fatty acids from different fat sources (High Oleic Canola, Canola, Canola-Flaxseed (3:1 blend), Safflower, or Soybean Oil, or a Lard-based diet) on adipose tissue function and markers of inflammation in Obese Prone rats fed high-fat (55% energy) diets for 12 weeks. Adipose tissue fatty acid composition reflected the dietary fatty acid profiles. Protein levels of fatty acid synthase, but not mRNA levels, were lower in adipose tissue of all groups compared to the Lard group. Adiponectin and fatty acid receptors GPR41 and GPR43 protein levels were also altered, but other metabolic and inflammatory mediators in adipose tissue and serum were unchanged among groups. Overall, rats fed vegetable oil- or lard-based high-fat diets appear to be largely resistant to major phenotypic changes when the dietary fat composition is altered, providing little support for the importance of specific fatty acid profiles in the context of a high-fat diet. (C) 2013 Elsevier Ltd. All rights reserved.